Once again!
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
Das S, Lin HS, Ho PC, Ng KY. Department of Pharmacy, Faculty of Science, National University of Singapore, Building S4, Rm 05-02, 18 Science Drive 4, Singapore, 117543, Singapore.
PURPOSE: This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol. METHODS: Water soluble intravenous and oral formulations of resveratrol were prepared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD), respectively. Sodium salt and suspension of resveratrol in carboxymethyl cellulose (CMC) were used as the reference intravenous and oral formulations, respectively. The pharmacokinetics of resveratrol was assessed in Sprague-Dawley rats. Plasma resveratrol concentrations were measured by high performance liquid chromatography (HPLC). RESULTS: Both HP-beta-CD and RM-beta-CD enhanced the aqueous solubility of resveratrol. After intravenous administration, rapid elimination of resveratrol was observed at all tested doses (5, 10, and 25 mg kg(-1)) regardless of formulation types; with non-linear elimination occurring at the dose of 25 mg kg(-1). RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension. Furthermore, the oral bioavailability remained unchanged among all tested doses (15, 25, and 50 mg kg(-1)). CONCLUSIONS: Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption. Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol.
Nothing new but thought I would point it out once again.... I think our HPMC is just the right thing
Dose on the Pharmacokinetic Profiles of Resveratrol
Started by
Hedgehog
, Jul 18 2008 10:28 PM
1 reply to this topic
#1
Posted 18 July 2008 - 10:28 PM
#2
Posted 19 July 2008 - 05:27 PM
Nice find Hedge, (as always)
I presume if you happen to have medium chain triglycerides and lecithin laying around your house, it may also do the trick....
A
I presume if you happen to have medium chain triglycerides and lecithin laying around your house, it may also do the trick....
A
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