15 replies to this topic

[dish]

One of the main objectives of many of the members at this forum is to increase the synthesis and hence the release of acetylcholine (ACh) from axonal terminals in the brain. ACh is implicated in learning and memory, and is the key neurotransmitter that is depleted in pathological memory diseases, like Alzheimer's disease.

At this forum, I notice that the most common approach to increasing brain levels of ACh is to ingest a ACh precursor, such as choline bitrate (or choline chlorine, choline citrate, etc). This is probably the most effective means of increasing ACh synthesis, since free choline in the blood plasma readily crosses the blood-brain barrier. Once in the brain's extracellular space, choline is then taken up by cholinergic nerve terminals by a high affinity choline uptake (HACU) system where it can combine with acetyl CoA to produce ACh. As can be seen, one of the rate-limiting factors in the synthesis of ACh is the rate at which this uptake of ACh occurs. Thus, if each member at this forum wants to increase ACh synthesis, one way to do it would be to increase the activity of the HACU system, which is sodium- and energy-dependent.

Since the HACU system is sodium- and energy dependent, I thought of supplements that could increase neuronal energy and facilitate the action of the sodium-potassium pumps that maintain the correct ion segregation across the neuronal membrane. Sure there are various metabolic enhancers that may increase neuronal energy, e.g. CoQ10, but what about (specifically) the Na-K pumps? There are a number of studies indicating that CDP-Choline can restore and enhance Na-K-ATPase activity. Does anyone have any further information concerning the effect of CDP-Choline on the Na-K pumps?

[nootropi]

The racetam family of drugs increase Ach receptors and receptivity.

Alpha GPC is an excellent choline source.

Both are available at smi2le.biz for reasonably cheap.

[todd_lee]

Does anyone have any further information concerning the effect of CDP-Choline on the Na-K pumps?

Answer the question Nootropi and stop advertising smi2le.biz

[scottl]

Why not combine a number of methods (being careful of dosage):

--e.g. alpha GPC and/or CDP choline +

--ACHe inhibitor e.g. galantamine or huperzine A (or...forget the name of Nootropis favorite aricept?) +

--racetam (or racetams)

[nootropi]

Answer the question Nootropi and stop advertising smi2le.biz

Stop criticizing me and actually contribute a comment that has some intellectual value. I searched your posts. All you have done here is either promote 1fast400 or criticize me.

Clearly you must think we are too foolish to make such correlations.

For the members here, let me give you a run down of all todd_lee's posts here, to prove my case:

todd_lee's posts:

1.  Thanks....

2.  Nootropi, there is no need to repeat yourself. That is just stupid.

3.  Stop making stupid posts, like...

4.  Nootropi (adamP2P), do I recall that you left that forum because you made an absolute fool of yourse...

5.  At the Avant board Nootropi (adamP2P) said that he is schizophrenic. This explains his paranoid beh...

6.  1FAST400, who assays your products?...

7.  Answer the question Nootropi and stop advertising smi2le.biz

Please try to add some constructive comments here rather than just spew negativity.

I am trying to help. I trust Rizzer enough to refer folks to him for certain items, I am not going to explain why again.

Edited by nootropi, 25 November 2004 - 02:50 AM.

[eternaltraveler]

nootropi you should stop advertising smi2le, esspecially now that people don't seem to be getting their orders. Surely this seems logical to you at least until these problems are resolved?

[magr]

I agree.

I have recieved 50% of my orders from him.

Sound good?

Order today!

[todd_lee]

nootropi you should stop advertising smi2le, esspecially now that people don't seem to be getting their orders.

I agree

[nootropi]

I like smi2le because smi2le is the best supplier of nootropics on the planet, which is my opinion, and I am entitled to it.

You guys should learn how to form your own opinions for yourself every once in a while. It shows you have the propensity to think for yourselves.

[todd_lee]

I like smi2le because smi2le is the best supplier of nootropics on the planet

You sound like a kid.

[stellar]

You sound like a kid.

You post like a troll.

[todd_lee]

And do I care?

[nootropi]

And do I care?

todd_lee: do you even realize how ridiculous you sound by such a response. Let me remind you of what you just said:

And do I care? [lol]

[unipolar_mania]

Adam K, just ignore them.

[omega_rage]

Wow, Unipolar_Mania is standing up for nootropi!
(I have been lurking here for a while) :D

[nootropi]

Wow, Unipolar_Mania is standing up for nootropi!
(I have been lurking here for a while) :D

Unipolar_Mania is not standing up for anybody. He is antagonizing me by not addressing me as my user name.