I am just interested if there's any drugs that actually kill the fear response in the brain?
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Advocacy & Research for Unlimited Lifespans
Posted 08 November 2012 - 06:25 PM
Posted 08 November 2012 - 07:04 PM
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Posted 08 November 2012 - 09:37 PM
I guess it really depends on the person... I tried both propranolol and atenolol, and I can assure you, propranolol gives me a much bigger anxiety reduction. Can you compare propranolol with (for example) benzos? Of course not... But what I mean is that propranolol can reduce fear by "detaching" the recall of the traumatic experience from the feelings associated with it. I think that's very useful for example in social phobia.Propranolol will mainly supress the phyical symptoms of anxiety, but doesn't do much for the mental aspect. Propranolol really is far away from being an anxiety eliminator although it's tremendously helpful for e.g. supressing panic attacks and many pysical signs of anxiety.
Edited by ricca91, 08 November 2012 - 09:37 PM.
Posted 08 November 2012 - 10:27 PM
Posted 08 November 2012 - 11:14 PM
Posted 09 November 2012 - 12:20 AM
Posted 09 November 2012 - 01:05 AM
Posted 09 November 2012 - 02:20 AM
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Posted 09 November 2012 - 03:39 AM
Methylene Blue has fear extinction properties
Posted 09 November 2012 - 05:11 AM
Methylene Blue has fear extinction properties
Where did you learn this? can you point to the thread or link?
Posted 09 November 2012 - 06:37 AM
Posted 09 November 2012 - 10:50 AM
The fear or 'fight-or-flight' response is mediated by the agonism of beta-adrenoreceptors. Hence the spike in sympathomimetic activity and the ensuing adrenaline rush one experiences when exposed to a perceptibly 'dangerous' or 'frightening' stimulus.
As such, beta-blockers are the answer to the OP's question.
Posted 09 November 2012 - 11:53 AM
I can also testify for this. The effect is not too large, but its definitely significant and its the main reason for which I am taking it right now (well technically to reduce anxiety at work).Methylene Blue has fear extinction properties
Where did you learn this? can you point to the thread or link?
Posted 09 November 2012 - 01:43 PM
Posted 09 November 2012 - 08:52 PM
Posted 10 November 2012 - 01:32 AM
Propranolol:
http://www.ncbi.nlm....pubmed/21525267
http://www.ncbi.nlm....pubmed/20381628
http://www.ncbi.nlm....pubmed/20102667
And D-Cycloserine:
http://www.ncbi.nlm....pubmed/15466301
Posted 11 November 2012 - 04:59 PM
Edited by Brainfogged, 11 November 2012 - 05:00 PM.
Posted 11 November 2012 - 07:40 PM
Posted 12 November 2012 - 06:40 PM
That doesn't sound like 'too much rationality' nearly as much as it sounds like motivations out of balance. Without compulsions (affective or otherwise) in play, a rational person could easily decide that a limit needed to be placed on time spent thinking about where to eat lunch, and that the best possible call would be to go with whatever seemed most favorable after that period of consideration.Read Damasio's book Descartes' Error. It's about people with brain damage that sort of killed their emotions and they had big problems in everyday decisioning - precisely because they were too rational. For example, one patient couldn't decide where to go to lunch - he would be thinking about each option for hours ... But this is not actually about killing fear. There are also some examples regarding amygdala damage after which people can't recognize or feel fear - but it doesn't affect their decisioning or "rationalizing" AFAIK.
Edited by Raza, 12 November 2012 - 06:40 PM.
Posted 12 November 2012 - 07:22 PM
That doesn't sound like 'too much rationality' nearly as much as it sounds like motivations out of balance. Without compulsions (affective or otherwise) in play, a rational person could easily decide that a limit needed to be placed on time spent thinking about where to eat lunch, and that the best possible call would be to go with whatever seemed most favorable after that period of consideration.Read Damasio's book Descartes' Error. It's about people with brain damage that sort of killed their emotions and they had big problems in everyday decisioning - precisely because they were too rational. For example, one patient couldn't decide where to go to lunch - he would be thinking about each option for hours ... But this is not actually about killing fear. There are also some examples regarding amygdala damage after which people can't recognize or feel fear - but it doesn't affect their decisioning or "rationalizing" AFAIK.
'Course, killing emotions selectively might well result in unbalanced motivations. Still, I think a dedicated rationalist with developed decision-making skills would deal with the absence of one or the other emotion far better than someone whose decisions will just fall back to the next most prominent motivation.
Posted 12 November 2012 - 08:17 PM
Posted 13 November 2012 - 03:02 PM
However, fear of death is not the ultimate fear. The ultimate fear is the loss of something of perceived value. For this, I have a method that emphasizes a kind of non-existence of self. Think about how the sense of who you are is created from moment to moment in a brain. And when you go to sleep, it momentarily shuts off. So you see, there is really nothing there to hold on to. It is all a simulation, and the only choice to be made is to make it a pleasant simulation shared with other fellow simulacra. And that includes not worrying about outcomes excessively, because ultimately, outcomes don't matter The paradox is that life feels better when we feel that outcomes matter, but not so good when we overemphasize their importance.
Also, no matter what happens in anyone's life, the universe will go on, and if the eternal chaotic theory of inflation is anything to shout about, then there are infinite universes that will go on forever, and therefore there is an infinite number of universes that are identical to this one, with people just like you having the same lives as your own.
A movie that helps with letting go is Fearless (1993, with Jeff Bridges).
This ending clip from the movie Sunshine also serves as a welcome reminder that you are not a separate thing, but are an infinitesimal part of the Happening that is this so-called reality. And no matter what happens, everything will be just as it was going to be. There is no 'free will' as such, and you are simply happening along with everything else.
Posted 13 November 2012 - 05:27 PM
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