Does anyone know about a service like this?
Surely we can get useful data from within the genotypes?
Posted 22 August 2013 - 10:44 PM
Posted 23 August 2013 - 01:41 PM
Posted 17 December 2013 - 09:36 PM
Posted 18 December 2013 - 02:11 PM
NutraHacker does this (www.nutrahacker.com)
We began with Dr. Yasko's list of genes then added genes from a wide range of topics such as:
Your report will clarify your specific genetic needs and deficiencies by explaining which mutations exist in your genome,
- Vitamin processing
- Liver detoxification
- Neurotransmitter metabolism
- Health conditions such as chronic fatigue syndrome, anxiety, and depression
what a normally functioning gene does and how a particular mutation affects your own health. Your report will include
informed and scientifically-based recommendations on supplementation to optimize your personal biology.
Posted 18 December 2013 - 09:53 PM
Where it gets dicey is with their advice. They don't say anything about the quality of the evidence it's based on, or about the magnitude of the effects one might expect from the errant SNP, which is kind of a recipe for a bum steer. In some cases the advice can be conflicting, telling you to take something for SNP 1 and to avoid it for SNP 2. I think the main value of this service is in bringing SNPs to your attention, but you should really do some research on that SNP before taking a substance on that basis. Essentially, they are over-interpreting the literature, if you ask me. You might very well find something useful in the report, but it would be up to you to separate the wheat from the chaff.
Posted 11 December 2014 - 06:21 PM
There's useful data in there, but I don't know of any company that will take your 23andMe results and tell you which supplements to take. I've seen at least one company that will do their own genetic testing (which probably isn't as good as 23andMe) and then sell you custom-selected overpriced supplements. I've forgotten their name... The best thing to do at the moment would probably be to download your 23andMe data, then upload it to Promethease. That's the best service I've seen so far for picking out the important/interesting stuff in your data. You could then look at the results, and ask around here regarding the treatment of anything that seems important. Two things you really should know about (that are hidden away in your 23andMe results) are your ApoE genotype and your folate metabolism type. The reason I think it's important to know these is that they both give you actionable information about diet and supplement/drug use that can have a significant impact on your health.
When translating the conventions from the SNPedia link you provide to the 23andme "language", the statement:
".. Homozygous rs1801133(T;T) individuals have ~30% of the expected MTHFR enzyme activity, and rs1801133(C;T) heterozygotes have ~65% activity, compared to the most common genotype, rs1801133(C;C)..."
should be read replacing (T;T), (C;T) and (C;C) with (A;A), (G;A) and (G;G) respectively, right? Just wish to be sure my understanding is correct as I am no expert
Posted 11 December 2014 - 11:18 PM
There's useful data in there, but I don't know of any company that will take your 23andMe results and tell you which supplements to take. I've seen at least one company that will do their own genetic testing (which probably isn't as good as 23andMe) and then sell you custom-selected overpriced supplements. I've forgotten their name... The best thing to do at the moment would probably be to download your 23andMe data, then upload it to Promethease. That's the best service I've seen so far for picking out the important/interesting stuff in your data. You could then look at the results, and ask around here regarding the treatment of anything that seems important. Two things you really should know about (that are hidden away in your 23andMe results) are your ApoE genotype and your folate metabolism type. The reason I think it's important to know these is that they both give you actionable information about diet and supplement/drug use that can have a significant impact on your health.
When translating the conventions from the SNPedia link you provide to the 23andme "language", the statement:
".. Homozygous rs1801133(T;T) individuals have ~30% of the expected MTHFR enzyme activity, and rs1801133(C;T) heterozygotes have ~65% activity, compared to the most common genotype, rs1801133(C;C)..."
should be read replacing (T;T), (C;T) and (C;C) with (A;A), (G;A) and (G;G) respectively, right? Just wish to be sure my understanding is correct as I am no expert
Yep, you're correct. a=t & c=g. See SNPedia's article on orientation here.
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