Has anyone tried a combo of d-cycloserine and baclofen (or a combo of substances with similar mechanisms of action)?
I suspect this may be a combo that would work very well for me but I feel it's uncertain whether it'd work long term.
Posted 01 January 2014 - 01:52 AM
Posted 01 January 2014 - 06:28 AM
Posted 01 January 2014 - 06:35 AM
I have never tried either drug, but have researched d-cycloserine significantly. I can provide you with more info on d-cycloserine depending on what you are trying to treat.
The GABA-B agonism from baclofen could lead to a nasty withdrawal should you discontinue taking it.
Posted 01 January 2014 - 07:09 AM
Posted 09 April 2014 - 12:26 AM
Ampamet? Anyone? Is there a source for d-cycloserine or minocycline?
Posted 09 April 2014 - 01:13 AM
You can get both from a doctor; they are both prescription antibiotics. Minocycline is commonly prescribed for infections, and cycloserine (or seromycin, as it is called in medicine) is much less commonly prescribed for TB and UTIs. Chances are you would get either from a psych after showing them relevant study info. The tricky part is getting insurance to cover it. Antibiotics are usually prescribed short term and in doses that may or may not be the same as those needed for psychopharmacological use. So you would need to figure out something about that, particularly for cycloserine which is expensive.
I have also seen foreign sources of cycloserine on alibaba and the like for decent prices. It's important to have any such products tested for purity before trying them.
Posted 09 April 2014 - 02:30 AM
New Star Nootropics has it I believe.
Posted 09 April 2014 - 02:53 AM
New Star Nootropics has it I believe.
I don't see either on their website.
Posted 10 April 2014 - 06:37 PM
Ok. Appreciate the quick reply Ampamet.
Posted 11 April 2014 - 02:42 AM
Chances are you would get either from a psych after showing them relevant study info.
If I recall correctly, when I last looked over the studies, D-cycloserine on its own will not do much good unless you combine it with CBT.
And even in CBT, what differs is the initial speed of learning, whereas the end results at the end of treatment were similar for subjects on D-cycloserine + CBT vs. subjects on only CBT. It appears to cause increased plasticity, which would not be useful unless one engages in behaviour correcting activities. Not sure what such activities would be in OCD - the studies so far seem to have focused on anxiety, right?
Posted 12 April 2014 - 04:34 PM
Chances are you would get either from a psych after showing them relevant study info.
If I recall correctly, when I last looked over the studies, D-cycloserine on its own will not do much good unless you combine it with CBT.
And even in CBT, what differs is the initial speed of learning, whereas the end results at the end of treatment were similar for subjects on D-cycloserine + CBT vs. subjects on only CBT. It appears to cause increased plasticity, which would not be useful unless one engages in behaviour correcting activities. Not sure what such activities would be in OCD - the studies so far seem to have focused on anxiety, right?
That is one use of cycloserine, as an NMDA antagonist to augment exposure therapy. But it is actually a partial agonist of the glycine site on the NMDA receptor; at higher doses it has different pharmacological effects. At doses > 1000 mg per day, it exerts an antidepressant effect. Check out the study below.
Posted 13 April 2014 - 12:30 AM
New Mind nootropics has d-cycloserine.
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