I got a kinda trycky question about drugs action on specific areas of the brain;
Take for example the NET-protein, handles reuptake of norepinephrine and in some areas also dopamin, the protein is expressed in many areas of the brain,
it (to me anyway) looks to be identical in all areas of the brain, but for some reason which i cannot find why, drugs dont inhibit the NET-protein in all areas of the brain, only specific.
An example would be the NET-inhibitor (NRI) Atomoxetine, brand name 'Strattera', it is used to treat ADHD which it does by inhibiting the NET-protein in the prefrontal cortex,
it does not seem to change NET-activity in say striatum, temporal cortices or any other area..
I've looked and seached the internet for clues, it may even be a simple answer to it, but i just cant find it..
Another thought i had about this is that reuptake inhibitors in general seems to be specific to areas, be it serotonin, noradrenaline or dopamine reuptake inhibitors,
they seem to only affect a certain area of the brain,
sometimes even lateralized, meaning on side or the other of the brain.
It may sound fuzzy, so please,
if you have question about what i mean, just question!