There is no such thing as a totally selective NRA, NRI, DRA, or DRI. It's impossible both in practice and in principle to produce such a compound, since the catecholamines are so similar in structure.
If you want a research chemical DRI, I would look into ethylphenidate. Fluoroamphetamines are popular as well, but they're extremely dangerous.
For this I have write ENOUGH selective.
Anyway, It's acceptable a monoamine releasing agent (MRA) with an high equilibrium dissociation constant (EDK) for 5HT (serotonin), and low for dopamine, and very low for norepinephrine.
SWIM don't want increase the level of serotonin.
d-amphetamine has a good binding profile (7; 110; 1,765).
SWIM is looking for an MRA with a similar profile: NE=[0,30]; DA=[0,200]; 5HT>800
http://en.wikipedia....releasing_agent
SWIM already know Ethylphenidate. It is an inhibitor and work more on dopamine than on norepinephrine.
Anyway it is enough good.
Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor.
http://en.wikipedia....Methylphenidate
Ethylphenidate acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor,
[...]
Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound,[4] but has significantly less activity on the norepinephrine transporter (NET).
http://en.wikipedia..../Ethylphenidate
SWIM is interested in releasing agents and inhibitors for norepinephrine and dopamine, but specially in NRA.
PS. Thanks for the replies
Edited by ken_shiro, 08 November 2014 - 08:55 PM.