Stumbled upon this:
It seems that too much Gdnf could be problematic according to this one
Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.
http://www.ncbi.nlm....pubmed/25101543
Catalpol increases GDNF in damaged tissue, but doesnt affect it in healthy tissue:
Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.
http://www.ncbi.nlm....pubmed/20123001
This one also increases GDNF:
Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.
http://www.ncbi.nlm....pubmed/22192054
derived from Scrophularia ningpoensis
Btw: According to this paper,
Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson’s diseas
http://wenku.baidu.c...175e0e4801.html
Rhizoma Polygonati and Fructus Ligustri Lucidi had stronger effects than Selegiline in increasing BDNF and NGF in MPTP treatet Mice, whereas herba epidemii ( horny goat weed) could restore Tyrosine Hydroxylase (TH) to baseline
...Herba Epimedii increased the BDNF level in the substantia nigra-striatum (36.33%).
Rhizoma Polygonati could increase BDNF and NGF levels (53.06%
and 15.91%, respectively) in the substantia nigra and striatum...
Rhizoma Polygonati = Polygonatum sibiricum
http://www.nutragree...-extract-powder
As usual, ask somebody about any interactions (e.g. bleeding) before usage, if You are interrested.
Edited by Flex, 04 January 2015 - 06:13 PM.