Thank you so much for taking the time to reply.
I'm really surprised to read that Selegiline doesn't increase sensitivity to PEA. I am a neophyte in the world of synapses but from what I had read, it was needed to decrease dosage of PEA when on selegiline. As per example, when I received them, I first tried the PEA and to get a bit of energy from it, the dosage was around 500mg (albeit short lived). After a few weeks on the selegiline the dose was 50-60mg. I concede that it could be placebo, but I'd be really surprised.
To give further details about Selegiline and Tianeptine (EOD only goes so far ) I would say I take the former 2-3 times a week and the latter 4-5 (only once usually in the evening, not the regular 3 doses a day). Your opinion on this administration would be welcome.
I used to take Beta everyday, I was experimenting with intermittent fasting and seeing if I could keep my shape even when cutting down the gym time to once a week. Indeed it works! It's almost magic. I can't train at the moment so stopped the creatine and beta.
No problem. Happy to help.
Selegiline shouldn't increase sensitivity to PEA per say. It will make PEA have a stronger effect on the person however this is because it is slowing down the metabolization of the PEA which is otherwise rapidly absorbed leading to a very short lived or unpronounced effect. To achieve a pronounced effect from PEA, people usually seem to take PEA in large enough doses to "tie up" your MAO enzymes or use a MAO inhibitor (such as selegiline) to slow the deamination/breakdown of PEA. Thus by using selegiline you would simply be slowing down the breakdown of the PEA in your system but not necessarily making yourself more sensitive to PEA itself.
Not much more I can say on the Selegiline and Tianeptine combo apart from what I already mentioned. Just be careful of overdoing the two in combination. This can lead to serious complications (seretonin syndrome). As mentioned high serotonin and/or dopamine levels also often results in a short temperament and irritability.
Personally, I would evaluate whether I really need those compounds and if so would only work with one at a time but thats just me as I find a naturalistic approach to my brain and mind health is much more efficient and healthier. Things like meditation and learning love and be loyal to oneself and be at one with the universe seem to work far better for me than various chemical influences I have tried. That however is too hippy for some
Btw Never stop anti-depressants cold turkey. May lead to nasty thoughts and sudden poor emotional wellbeing.
Also wouldnt suggest Beta-Alanine everyday. Agree its great for extra energy at the gym.
There has been some evidence that suggests it can cause a Taurine deficiency or a drop in your taurine intake levels due to the fact that it competes for the same transporter. Limited evidence however exists of such an effect in vivo.
See below from examine.com:
Taurine deficiency may not be a practical concern with conserved beta-alanine supplementation (with breaks, for cells to accumulate taurine), but excessive usage of beta-alanine and full-day dosing has not been studied in humans and has plausiblity for inducing a taurine deficiency
Also it does have some evidence that it alters your neurotransmitter levels in various regions of the brain. This can lead to unintended consequences (irritability etc.)
If you are concerned, cut it down to workout days or alternate days with Taurine.
Just wanted to add, you may be able to cut down to 1 day a week at the gym and maintain figure but cardio activity is important for healthy body, brain and mind function (definitely more than once a week).
Hope that helps
Edited by MadScientistX, 15 January 2015 - 01:16 PM.