Hi,
This has already been posted in the Rapamycin thread (thanks Pampaguy!), but I thought it was significant enough to deserve it's own thread, especially as it deals with a combination of drugs.
As I'm sure we would all agree, no single drug or supplement is going to significantly extend our lives, it will only be through combining them that we should see any substantial gains (at least prior to the arrival of senolytics).
Here, for the first time to my knowledge, a respected researcher has proposed just such a combination that would be eminently doable for those willing to accept an amount of risk. I'm certainly actively thinking about this for my parents who are in their mid seventies and perhaps even for myself if senolytics don't pan out in the next ten years (I'm 41).
This is quite similar to what Alan Green MD has recently started prescribing @ https://www.rapamycintherapy.com/ based on earlier work by the same researcher. (I have no affiliation with him)
From rapalogs to anti-aging formula
Mikhail V. Blagosklonny
Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
Oncotarget. 2017; 8:35492-35507. doi: 10.18632/oncotarget.18033
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.
At first, the discovery of anti-aging properties of rapamycin was met with skepticism because it challenged the dogma that aging is a decline driven by molecular damage caused by free radicals. By now, rapamycin has been proven to be an anti-aging drug. In contrast, anti-oxidants failed in clinical trials and the dogma was shattered. In the last decade, anti-aging effects of rapamycin have been confirmed. Anti-aging doses and schedules can be extrapolated from animal studies. Well-tolerated doses with minimal side effects can be deducted based on clinical use of rapalogs. So optimal anti-aging doses/schedules can be suggested. Given that rapamycin consistently extends maximal lifespan in mice, rapamycin will likely allow mankind to beat the current record of human longevity, which is 122 years. Yet, rapamycin will not extend life span as much as we might wish to.
Now is the time for anti-aging drug combinations. For example, metformin is currently undergoing re-purposing as an anti-aging agent. Several other existing drugs can be re-purposed. Now we can design an anti-aging formula, using drugs available for human use. However, we must first discuss the link between growth, aging and age-related diseases.
http://www.impactjou...33&path[]=57761
Blagosklonny 7 Drug Anti-Aging Formula 2017.pdf 714.5KB 49 downloads
What do you think about this combo? Is it realistic? Would you take anything out/add anything in? Interesting that there is no mention of NR.