3 replies to this topic
#1
Posted 22 February 2018 - 03:31 PM
so I was reading about modafinil on wiki it said modafinil inhibits DAT(DOPAMINE TRANSPORTER) 51% which is a lot so it increases dopamine. But I came across a comment that said the following: modafinils ability to increase dopamine signalling is weak compared with amphetamine's ability to increase dopamine signalling, however.
what does that mean? Like ADHD Drugs inhibit more than 51%??? How much do smart drugs inhibit DAT ? Like 90%?
what does that mean? Like ADHD Drugs inhibit more than 51%??? How much do smart drugs inhibit DAT ? Like 90%?
#2
Posted 23 February 2018 - 07:44 AM
It means... that even though it can cause a 51% decrease of DAT, it still only means that a very small percentage of the drug actually attaches to DAT - it attaches to a bunch of other things first, and affects them - there's not much of the drug left to actually affect DAT.
Only if you use ludicrous (as in, DANGEROUS!) dosages of Modafinil will you see a 51% decrease of DAT.
Most smart drugs/nootropics, have a different mode of action than effecting DAT, or even dopamine neurotransmission -systems at all - most of them affect something called Acetylcholine. (most of the racetams, cdp-choline, alpha-gpc, even Omega-3)
#3
Posted 23 February 2018 - 12:15 PM
It means... that even though it can cause a 51% decrease of DAT, it still only means that a very small percentage of the drug actually attaches to DAT - it attaches to a bunch of other things first, and affects them - there's not much of the drug left to actually affect DAT.
Only if you use ludicrous (as in, DANGEROUS!) dosages of Modafinil will you see a 51% decrease of DAT.
Most smart drugs/nootropics, have a different mode of action than effecting DAT, or even dopamine neurotransmission -systems at all - most of them affect something called Acetylcholine. (most of the racetams, cdp-choline, alpha-gpc, even Omega-3)
is 300mg a lot? because according to wiki that was the dosage used and they saw an occupancy of 50%.
from Wiki
"modafinil is an exceptionally weak, but apparently very selective, [DAT] inhibitor".[46] In addition to animal research, a human positron emission tomography (PET) imaging study found that 200 mg and 300 mg doses of modafinil resulted in DAT occupancy of 51.4% and 56.9%, respectively, which was described as "close to that of methylphenidate"
#4
Posted 12 April 2018 - 06:17 PM
bump im still confused about this.. ??
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