4 replies to this topic

[Daniel Cooper]

If a person has an issue with HPA axis dysregulation, does anyone have any speculation on whether beta blockers are likely to help or hurt restoring the HPA axis operating point?

 

 

 

 

[Galaxyshock]

Beta blocker makes you alpha as it blocks the beta (guy with hands shaking).

[prunk]

For some reason propranolol makes me slightly aggressive.

[PabloHoney825]

Propranolol and Atenolol are the two most commonly prescribed for agitation/anxiety/and benzo or alcohol withdrawal/tremor/hyperarousal/adrenaline off-label for panic etc. Propranolol has weak antagonism of serotonin receptors though. Propranolol may cause insomnia as it impedes melatonin but you could always supplement a low-dose melatonin which is commonly suggested for those on beta blockers who experience insomnia.

 

As I'm currently in anti-depressant withdrawal and on Propranolol, I wonder if the antagonism is helping or harming my recovery. My serotonin 5HT receptors are down-regulated from mirtazpaine use and withdrawal and I believe antagonists upregulate receptors? 

Edited by PabloHoney825, 17 March 2018 - 05:24 PM.

[Galaxyshock]

For some reason propranolol makes me slightly aggressive.

 

Beta blockade leads to increased activity at alpha-adrenergic receptors and possibly compensatory increase in noradrenaline levels.