What are some CRF1 antagonists?
YOLF 06 Jun 2018
Have you been genotyped with 23andMe? I'd like to take a look and see what you mean by speed mode... You can cut off adrenaline output with several things, or increase receptor competitors that are also anxiolytics.
. I believe I have too many crf1 receptors/activation in the brain and this is causing my anxiety and increasing ACTH. I have an appointment with my doc in like 3 weeks. is it possible to test ACTH levels? Is it possible to measure CRH?,is it true you cant test for crf1?
This is all just speculations based on my SNPS/genes and various drugs ive tested.
Well dont have to nessicary kill it off 100% but just balance it . is there a video of these interviews?
and my grammar is horrible becuase of this .. im in a constant speed mode .. this all relates to CRF activation..
Have you ever taken protein with added BCAAs? Lots of other GH releasers.
growth hormone
https://www.ncbi.nlm...pubmed/16912060
St John's wort
https://www.ncbi.nlm...pubmed/11526469
Of Astressin-B:
In 2011, research showed that treatment with astressin-B caused the sudden growth of hair in mice bred for a propensity for stress.
That's pretty cool, the product also has copper containing peptides. Have you tried it? It would seem that it could address a variety of aging issues and depending on what Astressin-B peptide is, it could even reach circulation when applied topically like other hair treatments. I'm guessing that even if you're wrong, this one would be a useful purchase.
Edited by YOLF, 06 June 2018 - 04:49 AM.
kurdishfella 06 Jun 2018
Have you been genotyped with 23andMe? I'd like to take a look and see what you mean by speed mode... You can cut off adrenaline output with several things, or increase receptor competitors that are also anxiolytics.
Have you ever taken protein with added BCAAs? Lots of other GH releasers.
Of Astressin-B:
That's pretty cool, the product also has copper containing peptides. Have you tried it? It would seem that it could address a variety of aging issues and depending on what Astressin-B peptide is, it could even reach circulation when applied topically like other hair treatments. I'm guessing that even if you're wrong, this one would be a useful purchase.
yes ive used 23andme. i ran it trough a site and it says I have mutation in my CRF1 gene which I have no idea what they are.
CRHR1-IT1 (CRHR1 intronic transcript 1) & MGC57346-CRHR1 2.35. All the info I have is they are both associated with Corticobasal Degeneration®. It is reported to increased association with Corticobasal degeneration. Does that mean lower CRF1 activity? Anyway I suspect I have excess CRF1 levels due to a tumor that secrets it.
https://www.longecit...ve-crh-or-acth/
Astressin B blocks CRH I tried to order it but not allowed where I live for some reason.
I doubt it will get absorbed tho..
yes I have taken protein with BCAA , why?
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YOLF 06 Jun 2018
You mentioned GH, I was wondering how the BCAAs affected your 'speed mode.' I've skimmed the study now though... it'll need more attention.
kurdishfella 06 Jun 2018
I think bcaa helped a little with my headache other than that I don´t think I noticed anything else.
kurdishfella 06 Jun 2018
pregnenolone decreases CRH by converting to progesterone which then converts to 5α-DHP then allpregnenolone which is how it inhibits CRH.
There is a guy that sells plain 5α-DHP on Raypeat gonna try it out. This has to be the best way to inhibit crh.
YOLF 06 Jun 2018
They make progesterone creams for women. Application on sensitive areas will make it to the bloodstream in sufficient quantities.
It looks like progesterone was also used once upon a time as a partially effective hair loss treatment. I image there are combination therapies that could rival finasteride.
kurdishfella 11 Jun 2018
whats the difference between the 50:1 extract and the dry powdered ginkgo?
kurdishfella 12 Jun 2018
sulforaphane increases the expression of the enzyme 3alpha-HSD which is responsible for converting DHP into allopregnanolone (GABA-A modulator, inhibits CRF release)
kurdishfella 24 Jun 2018
Hyperflux 24 Jun 2018
What are the nootropic and hormonal benefits of 5a-DHP? There's a 36 page thread on Ray Peat forums.
kurdishfella 24 Jun 2018
https://en.wikipedia...ogical_function
Allopregnanolone possesses a wide variety of effects, including, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding,[21] prosocial,[22] antiaggressive,[23]prosexual,[22] sedative, pro-sleep,[24] cognitive and memory-impairing, analgesic,[25] anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.[2]
Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[29][30][31]
5a-dhp main effects come from this, 5a-dhp on its own I don't think it does much.
Edited by farshad, 24 June 2018 - 11:21 PM.
kurdishfella 25 Jun 2018
are ginkgo biloba faked a lot? Im taking capsules now but before I took a powder with juice, but the capsules doesen'´t seem to be working..is powder absorbed different/better?
kurdishfella 26 Jun 2018
1g+ ginkgo biloba didn't work but 2g+(20 capsules) did ..... too many capsules and expensive to take everyday.. gonna skip ginkgo biloba.
Edited by farshad, 26 June 2018 - 07:47 AM.
kurdishfella 06 Jul 2018
it is the hypericin content not Hyperforin that decreases CRH: https://www.ncbi.nlm.nih.gov/pubmed/12865894
Edited by farshad, 06 July 2018 - 05:59 PM.
kurdishfella 08 Jul 2018
GABA receptors are significantly involved in fear memory and fear conditioning.
GABA receptors regulate a stress response hormone (corticotropin) when GABA receptors are excited
GABA (GABA-A? OR B?) is the main inhibitory neurotransmitter in the brain, meaning that it prevents our neurons from over-firing and being over-stimulated.
kurdishfella 16 Jul 2018
GABA and Cortisol (good read)
https://www.drlam.co...out-gaba/15864/
Btw I think fasting increases GABA which would lower crh.
Edited by farshad, 16 July 2018 - 02:09 PM.
kurdishfella 17 Jul 2018
to my surprise, GABA-B doesen't inhibit CRH release, only GABA-A does.
GABA-A Indirectly supress the amygdala, which in turn prevents the release of CRF:
I know GABA-A and GABA-B are receptors of GABA, so on its own does GABA have any function or is it just there to activate the two receptors?
kurdishfella 30 Jul 2018
so I have figured out my situation a little more.. as Ive been saying I have increased CRF1 activity (not CRH OR CRH2) , cause at the moment : unknown but refer to my other post to see some possible causes: https://www.longecit...th/#entry854058 #post 15
may update later if I find other possible causes.
Anxiety is more affected by GABA-a agonism than CRH antagonism. CRH antagonism have more effect on how well you handle stress.
Now my plan was to take 5a-dhp a precursor to allopregnanolone potent modulator of GABA-A, BUT... it will not decrease the CRF1 activity it will only inhibit its release and help with anxiety. But it will not help me handle anxiety better. So I need a CRF1 Antagonist.......... IE antalarmin (dunno where to get these)
second, Ginkgo biloba has been shown to reduce CRH , so this could possible slow down my CRF1 activity, only problem is I dont know if it is CRH only or CRF1 too. study says only CRH.
https://www.gaiaherb.../32/Ginkgo-Leaf
third: st johns worth has been shown to reduce CRH by 20% after 8 weeks, again studies only mention CRH not CRF1 so dunno if that will help either.
https://www.gaiaherb.../St.-Johns-Wort
Edited by farshad, 30 July 2018 - 11:42 PM.
kurdishfella 01 Aug 2018
HDAC inhibitors downregulate CRH expression.
Transcription of the CRH gene requires recruitment from histone deacetylace 4 (source). Therefore, substances that inhibit histone deacetylace 4 (sodium butyrate and thymoquinone from black seed oil/nigella sativa both do) should decrease transcription of the CRH gene.
studies have shown the HDAC inhibitor valproic acid (depakote) can decrease CRF1 binding in the amygdala and hypothalamus.
HDAC inhibitiors:
Vorinostat
Curcumin
tacedinaline
gamma-hydroxy-butyrate (GHB)
beta-hydroxy-butyrate (BHB)
Cl-994
Crebinostat
phenibut
egcg
granny smith green apples affect gut butyrate which may act as hdac inhibitor.
RG2833
trichostatin A
pterostilbene
resveratrol
Parmesan cheese
butter
Bacopa
Metformin
Berberine
Indole-3-carbinol
L-Carnitine
sulforaphane
Apple cider vinegar
kurdishfella 02 Aug 2018
ok heres the ultimate fear extinction stack ive come up with lemme know your thoughts:
tribulus - possible reduce crh
st johns worth - reduce crh by 20%
ginkgo biloba - slows down crh secretion
memantine - alpha 7 antagonist (alpha 7 nicotinic receptor controls amygdala activity but memantine is weak need a stronger one but it has a long half life) alternative BNC-210 or somth if you can get it.
5a-dhp / progesterone / pregnenolone - precursor to allopregnenolone potent modulator of gaba-a which inhibits crh
Vorinostat/ black seed oil/sodium butyrate etc - HDAC inhibitors decrease fear a lot
valproic acid (depakote) - decrease CRF1 binding in the amygdala and hypothalamus.
marijuana or synthetic cb1 drugs -CB1 agonists decrease anxiety
Antalarmin or Pexacerfont or astressin b - Antagonist on CRF1 and CRH(ie both crf1/crf2)
kurdishfella 02 Aug 2018
Valproate (depakote) decreased CRH release in rats, whereas lamotrigine stabilized ACTH/cortisol secretion. Moreover, felbamate was found to inhibit stress-induced corticosterone release in mice. Interestingly, recent data suggest that felbamat and some other new antiepileptic drugs may inhibit transcriptional activity of glucocorticoid receptors. Summing up, the above data suggest that traditional antiepileptic drugs may cause endocrine disturbances, especially in gonadal hormones.
Edited by farshad, 02 August 2018 - 04:09 PM.
kurdishfella 02 Aug 2018
i wonder would wellbutrin + memantine together potently block alpha niconic receptor 7? both are antagonists on that but weak especially wellbutrin.
kurdishfella 03 Aug 2018
Allpha-7's (α7-Containing nicotinic acetylcholine receptors) are located on the interneurons of the basolateral amygdala, which controls and regulates how hyphy your neuro-network is going to be for the moment, also Notch receptors, trkB and trkC receptors, and androgen receptors; and any ligand that stimulates the dorsolateral prefrontal cortex will decrease activity in the amygdala.
kurdishfella 03 Aug 2018
kurdishfella 04 Aug 2018
Clonidine, Cabergoline, Raloxifene inhibit HPA axis, leading to lowered CRH and ACTH.
CRH/ACTH inhibitors
Serotonin antagonists: cyproheptadine, ketanserin, ritanserin, metergoline
Dopaminergic agonists: bromocriptine, cabergoline Catecholamine depletors: reserpine GABAergic agents: valproic acid
Somatostatin analogues: octreotide, lanreotide, pasireotide Peroxisome proliferator-activated receptor (PPAR-c) agonists: pioglitazone, rosiglitazone
Steroid synthesis inhibitors Single enzyme inhibitors: metyrapone, trilostane Multiple enzyme inhibitors: mitotane, aminoglutethimide, ketoconazole, fluconazole, etomidate
Glucocorticoid receptor antagonists Mifepristone (RU486)
You want to read this:
?prednisolone?
more hdac inhibitors
https://en.wikipedia...ylase_inhibitor
Edited by farshad, 04 August 2018 - 03:57 PM.
kurdishfella 06 Aug 2018
does lithium decrease CRH?
''Lithium administration decreased CRF(1) mRNA expression in both the amygdala and frontal cortex''
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kurdishfella 09 Aug 2018
Alprazolam(xanax), a benzodiazepine derivative, stimulates specific gamma-aminobutyric acidA receptors and has been found to inhibit CRH activity in the brain.
In this patient, the acute drop in serum cortisol might be due to overdose of clonazepam that can inhibit CRH
+ more benzos possibly
Edited by farshad, 09 August 2018 - 08:57 AM.