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Low Dopamine Genes

dopamine

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#1 kurdishfella

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Posted 14 April 2018 - 10:36 PM


I have a few mutations in my dopamine genes im curious about:

 

https://www.selfdecode.com/gene/drd1/

https://www.selfdecode.com/gene/drd2/

https://www.selfdecode.com/gene/drd3/

 

https://www.selfdecode.com/gene/th/ (maybe I dont  have any mutations here)

https://www.selfdecode.com/gene/dbh/ (mutation implying  low norepinephrine but high dopamine? (not sure here)

https://www.selfdecode.com/gene/comt/ (mutation implying I have low COMT so High dopamine? dont know for sure here either)

 

what drug can fix each of these issues?

 

I can take a dopamine agonist like  pramipexole for the first 3 links (even tho Pramipexole isnt an agonist on Dopamine receptor 1 but its just an example)

 

what about the other 3? TH ,DBH and COMT? wtf are those and how do I fix them? Do genetic mutations in those cause low or high dopamine and do I wanna increase or decrease those?

 

Maybe all I need is a dopamine agonist drug that hits D1,D2 and D3 . Does hitting the D2 receptor  with drugs also hit the  D2Sh (short) and D2Lh (long)?


Edited by farshad, 14 April 2018 - 10:51 PM.


#2 kurdishfella

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Posted 14 April 2018 - 11:23 PM

 Dopamine drug that are agonist on D1,D2 & D3?

Anybody know of a drug that is an agonist on all these 3? Bromocriptine is a agonist on them but its weak on D1. Pramipexole doesent Hit D1. cabergoline is weak on D1 also. Just for future reference , any drug that actually hits ALL these 3 dopamine receptors and are not weak? especially on D1 .


Edited by farshad, 14 April 2018 - 11:24 PM.


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#3 kurdishfella

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Posted 15 April 2018 - 01:18 AM

oh wow theres a whole bunch more https://www.selfhack...amine-function/



#4 kurdishfella

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Posted 15 April 2018 - 02:05 AM

more mutations:

 

https://www.selfdecode.com/gene/htr2a/

https://www.selfdecode.com/gene/park2/

https://www.selfdecode.com/gene/snca/

https://www.selfdecode.com/gene/agtr2/

https://www.selfdecode.com/gene/gch1/

https://www.selfdecode.com/gene/tgfb2/

https://www.selfdeco...m/gene/slc22a3/

https://www.selfdeco...m/gene/slc22a2/

https://www.selfdeco...m/gene/slc22a1/

 

btw disregard the TH gene   in first post I dont have mutations in that gene.


Edited by farshad, 15 April 2018 - 02:07 AM.


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#5 kurdishfella

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Posted 15 April 2018 - 12:42 PM

wonder why selfhacked didnt mention the 5ht2c gene when its blocked dopamine is increased in one part of the brain ,anyway I had no mutation with it anyway.







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