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Increase GABA

gaba

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#1 farshad

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Posted 12 June 2018 - 06:21 PM


what are some supplements that increase GABA? from what I have read GABA is the best way to counteract anxiety correct? I notice there are few different GABA's, A and B etc, which one is the best for stress/anxiety?

 

 

is this description correct? 

There are two types of GABA receptors in your brain: GABA(A) and GABA(B) receptors. GABA(A) receptors generally produce feelings of sedation while GABA(B) receptors are responsible for feelings of relaxation and euphoria. 

 

 


Edited by farshad, 12 June 2018 - 06:36 PM.


#2 farshad

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Posted 15 June 2018 - 06:48 PM

is GABA - A more for CRF1(cortisol releasing hormone 1) and GABA-B is more for CRF2?

 

Supposedly both GABA A & B are anxylotic but in different ways? I take it GABA-A is better for anxiety since benzodiazeines target that.

 

also is it true if you use a high enough dosage on   GABA-A drug it will also upregulate B?


Edited by farshad, 15 June 2018 - 07:05 PM.


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#3 Believer

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Posted 16 June 2018 - 06:38 AM

Low dose pregnenolone is excitatory whereas very high dosage (100mg+) is inhibitory via gaba activity.

Keto diet directly increases glutamate to gaba conversion.

Vitamin B5 has strong gabaergic effects via increasing 5-ar activity.

 

Gaba-b can actually produce a specific schizo anxiety but can also alleviate some specific anxiety like the fear of eye contact in autism which is caused by lack of gaba-b activity.

Gaba a is more inhibitory.


Edited by Believer, 16 June 2018 - 06:40 AM.

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#4 farshad

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Posted 16 June 2018 - 08:15 AM

Low dose pregnenolone is excitatory whereas very high dosage (100mg+) is inhibitory via gaba activity.

Keto diet directly increases glutamate to gaba conversion.

Vitamin B5 has strong gabaergic effects via increasing 5-ar activity.

 

Gaba-b can actually produce a specific schizo anxiety but can also alleviate some specific anxiety like the fear of eye contact in autism which is caused by lack of gaba-b activity.

Gaba a is more inhibitory.

I always wonder what the difference was between GABA A and B.

I assume GABA-A  is better for anxiety since most benzodiazepines act on GABA-A? GABA-B I think decreases fear/make you more confidence, and gaba A decrease anxiety, if that makes sense... that is just my thoughts no proof of it.

 

I have tried Lyrica and phenibut which are agonist on GABA B I think and they did make me relaxed but my Anxiety was still there. But GABA-A I have yet to try increase.

 

I have tried pregnenolone and progesterone, they didnt help with my anxiety for some reason, Im guessing I lack the 5-ar enzyme or something for them to convert into allopregnenolone.  I also read somewhere topical progesterone not much of it is converted to allopregnenolone , so progesterone needs to be taken orally to get that conversion.

I saw a thread on  a forum  about a hormone called 5a-dhp which is supposed   to increase   allopregnenolone which increases GABA-A. So im gonna give that  a shot.

 

On reddit lots of people talk about: theanine,taurine none of which worked for me . picamilion is another but i havent tried. Lots of GABA supplements dont work for me for some reason, I guess they dont work as good as hormones or something so 5a-dhp im hoping works .

 

I know GABA-A indirectly decreases Crh(cortisol releasing hormone) but GABA-B I dont know if it does .

 

I read somewhere that if you use a high dosage on GABA B it will increase GABA a too dont know if thats true.


Edited by farshad, 16 June 2018 - 08:48 AM.


#5 farshad

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Posted 16 June 2018 - 10:47 AM

If anyone has a huge list of GABA agonists please post below



#6 medievil

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Posted 16 June 2018 - 01:13 PM

Picamilon is gaba tied to a vitamin which crosses the BBB and agonises both GABAA and GABAB, its effects are mild, it anecdotially induces some nootropic type effects.

Phenelzine, a MAOI that has a metabolite which induces reuptake of GABA, supposedly makes it a superior MAOI and highly effective for SA, as it also acts on all other implicated neurotransmitters.

GABOB, also agonises both gaba receptors, is a mild anticonvulsant.

Tiagabine, a gaba reuptake inhibitor, I made a overview of the therapeutic effects it has for the treatment of mental illness.

GHB, acts as a GABAB and GHB receptor agonist, therapeutically used for alcohol addiction, in some people it caused ppl to get addicted to it but the addition of naltrexone took away the addictive rewarding effects according to a few case reports, making it a potential therapeutic drug for a lot of mental illnesses.

Phenibut, feels like a mild version of GHB, anecdotes report potent anxiolytic effects but rapid tolerance occurs and there are hororstories of terrible withdrawal after taking it longer then 3 days, but a few days of baclofen or clonazepam/diazepam abloriates the withdrawal painlessly and easily, according to anecdotes including my own.

Baclofen, lacks the potent anxiolytic effects of GHB and phenibut but works effectively for promoting rational decision making and addiction according to several anecdotes, many anecdotes confirm it completely removes alcohol addiction during taking it, craving and withdrawal making it a painless agent for the treatment of alcoholism, several books are written on it.

Muscimol, is a potent gabaa and gabab agonist with mild hallucinogenic effects.

KAVA KAVA, upregulates GABAB

Magnolia bark, a herb as potent as a low dose of diazepam and according to a anecdote dramatically potentiates phenibut by some mechanism.

Nefiracetam, increases GABA in the brain.

Fasoracetam upregulate GABAB

 

I'm sure I'm forgetting a couple, but this should get your research started.


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#7 medievil

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Posted 16 June 2018 - 01:26 PM

This is my research topic on tiagabine for the treatment of mental illness..



#8 Galaxyshock

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Posted 17 June 2018 - 06:59 AM

Gotu Kola increases GABA biosynthesis through induction of GAD enzyme, and Gotu is also a selective GABA-B agonist.


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#9 farshad

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Posted 17 June 2018 - 05:35 PM

Guys... Which GABA is better for decreasing CRH(cortisol releasing hormone)? I saw these 2 studies but my english is limited I have hard time understanding.

 

GABA B - https://www.ncbi.nlm...pubmed/21236282

 

GABA A - https://www.ncbi.nlm...pubmed/10723009

 

What do they say? should I go for GABA A or B? 



#10 farshad

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Posted 18 June 2018 - 11:36 AM

Would Fasoracetam be a good option to increase GABA-B? Im not sure it increases GABA-B? 

cause i need a better alternative then.


Edited by farshad, 18 June 2018 - 11:38 AM.


#11 Galaxyshock

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Posted 21 June 2018 - 07:52 AM

Magnolia bark, a herb as potent as a low dose of diazepam and according to a anecdote dramatically potentiates phenibut by some mechanism.

 

I didn't notice any significant potentiation of Phenibut from Magnolia bark, but it's pretty decent anxiolytic herb.

 

Licorice on the other hand may potentiate PB as it seems to contain a GABA-B modulator:

https://www.ncbi.nlm...pubmed/18495107

 

A teaspoon of Licorice extract gets me a bit high, but this could also be through other mechanisms.



#12 Nate-2004

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Posted 22 June 2018 - 06:54 PM

I've done a lot of reading about both GABA and glutamate lately. So far there aren't any GRAS supplements being sold that boost GABA levels specifically, not without also boosting glutamate, taurine for example. There are a number of ways to boost GAD, i.e. Gabapentin, which can help boost GABA indirectly, though this may not have the effect you're looking for depending on what you're aiming at. 

 

 

There's a list in Table 1 of this pharmacological review on essential tremor, a glutamate/GABA related condition, here's a direct link:

 

https://www.ncbi.nlm...port=objectonly

 

 

 


Edited by Nate-2004, 22 June 2018 - 06:55 PM.


#13 Daniel Cooper

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Posted 26 June 2018 - 03:13 PM

Vagus Nerve Stimulation seems to increase GABAA receptor density in drug resistant partial epilepsy:   

 

 

https://www.research...artial_epilepsy

 

Now, this study is of implantable vagus nerve stimulators, but one might surmise that a similar effect is possible with transcutaneous vagus nerve stimulation (tvns).  

 

Implantable VNS patients have reported decreased anxiety and remission of seizures even after the stimulator was turned off or removed, so the increase in GABA receptor density may be persistent.  

 

I would think this would be relevant to both anxiety and essential tremor.

 

 

 

 

 


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#14 Rocket

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Posted 29 June 2018 - 10:48 PM

I think it's time you change your name to Robert Rackstraw!  :)


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#15 Daniel Cooper

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Posted 30 June 2018 - 01:56 AM

Shhhhhh!   ;)







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