"... Similarly, CB 1 receptors are also coupled to ERK cascades and the proneurogenic action of cannabinoids seems to be related to facilitation of ERK signaling [91, 122, 123]. Also, brain derived neurotrophic factor (BDNF), a neurotrophin that is found reduced in depressed patients, and that is up regulated after AD or cannabinoids treatment could be involved [121,124125126127. This neurotrophic factor has been implicated in adult hippocampal neurogenesis [128]. ..."
...Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?
https://www.research...l_of_depression
Cannabinoids are pro-neurogenic neuroprotective-antioxidants.