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Retinoids and fat loss/aging skin

retin-a tretinoin anti-aging

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#1 miss_vaanjie

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Posted 14 July 2018 - 03:24 AM


Retin-A is presented to be the traditional gold standard in dermatology when it comes to anti-aging, but I've seen an increased amount of reports of facial fat loss/hollownesss/sagging in young users.  I find this to be concerning, particularly when many doctors encourage people to begin usage at fairly young ages for the purpose of anti-aging.

 

After spending a lot of time analyzing research on PubMed and encountering studies such as thisthisthisthis, and many more,  I feel I confirm that retinoic acid directly impairs the process of adipogenesis by inhibiting adipocyte differentiation in several ways both in vivo and in vitro.

 

 I love performing research but I'll be the first to admit that I do not have a science background, so I ran my theory by one of the scientists who writes on the blog BareFacedTruth.  *FYI these doctors have created several skincare products, most based on stem cell cytokines, but also sell products containing retinol. That being said they openly admit a certain level of bias but also freely recommend other skincare brands, and do an absolutely amazing job of explaining skincare science.)

 

I received this response: 

 

"it is well known that all trans retinoic acid reduces expression of adipogenic transcription factors (e.g. PPAR-gamma) and increases fat oxidation. Short-term administration of isotretinoin can even elevates plasma triglyceride concentrations. Suspicious huh? The effect on subcutaneous fat is not at all clear (mostly “ignored” in the medical literature), but switching to an oxidative metabolism is surely suggestive of disrupted lipogenesis, which would at the least interfere with normal tissue maintenance. So your theory may not be all that unorthodox, although poking the sleeping bear (retinoids being all that many dermatologists believe in for anti-aging) could earn you a reputation as a muckraker. Please share your data or observations....Certain native human growth factors can contribute to restoration of fat stores. Facial adipose fat cells have receptors for e.g. IGF-1, and TGF-B3. The response to topical signaling is is growth (mitogenic) and differentiation. Plastic surgeons are gaining experiencing in using GF and cytokine stimulation, typically through autologous stem cell enrichment, to aid in the engraftment of transplanted fat for facial volume enhancement."

 

So while formal research hasn't really looked into fat loss resultant from tretinoin specifically, there is pretty solid reasoning in being concerned. As far as ways to combat this go, stem cell cytokine products that upregulate IGF-1 and TGF-B3 would be helpful as mentioned above and I've read that azelaic acid activates PPAR-gamma as well. I’m continuing research on peroxisome proliferator-activated receptors and the importance of CCAAT/enhancer-binding protein in fat production. but this is what I've got so far.  

 

If anyone has any experience or info related to this topic, I'd love to hear about it.  Most people in the skincare community, dermatologists included, are not willing to question the efficacy of retinoids but no product is above scientific scrutiny and I firmly believe there are better ways of addressing aging skin. 


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#2 Adamzski

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Posted 14 July 2018 - 06:23 AM

I have been considering to start retin-a again. Am concerned about it going systematic and causing cancer. There is that study https://www.ncbi.nlm...les/PMC2918338/ .

 

If I do start using it it will be just used directly on lines.



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#3 Nate-2004

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Posted 17 July 2018 - 06:10 PM

Thanks for this, was just about to see a dermatologist about my rosacea and maybe get tretinoin, this kind of discourages me from going that route.


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#4 ForeverBulking

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Posted 02 August 2018 - 04:25 PM

I am not a fan of retinoids at all. I used them a lot when I was 19-21 and they prematurely aged my skin. Now at 29, people think I am in my late 30's.



#5 Adamzski

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Posted 09 August 2018 - 03:13 AM

Thanks for this, was just about to see a dermatologist about my rosacea and maybe get tretinoin, this kind of discourages me from going that route.

 

 

I don't think you are a smoker? If not smoking then I think its ok, but then we get enough second-hand smoke and environmental pollutants anyway. So yeah read up on it more.

The study participants were very old, they were using it all over their face each night, don't know how much. 

 

If you did want to treat rosacea in just a certain area it may be fine to just use it sparingly on that area.

 

Also, this Retin-A has been used by so many people for so long, no one has dropped dead from it. Im still not sure about it and will research more before i try it again.



#6 Moondancer

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Posted 09 August 2018 - 03:23 PM

What about using it for half an hour on the entire face and then washing it off? Would it be less of an issue then?



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#7 Adamzski

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Posted 11 August 2018 - 09:41 PM

What about using it for half an hour on the entire face and then washing it off? Would it be less of an issue then?

 

 

Yes, it could be, but it goes systematic. Back in my fighting hair loss days, we used Retin-a to increase the absorption of minoxidil (Rogaine).

 

Washing it off could even take it into the body more.

 

If it really does cause fat loss then I may start using it again just under my eyes to get rid of bags.







Also tagged with one or more of these keywords: retin-a, tretinoin, anti-aging

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