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Dr. Conlon says long term NAD precursor supplementation is pointless, claims to have new cocktail that works

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#31 Gayle63

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Posted 12 April 2019 - 04:39 PM

She also says in her Undoing Aging talk that the 57 year old who the cocktail was tested on showed the NAD levels of a 19 year old after two weeks (they didn't test it for longer).

 

This is the talk (camera doesn't show the slides with the results though, unfortunately).

 

Thank you very much for sharing that! I'll watch it tonight whilst I'm on the dreadmill. :)

I hope it's not too expensive -- I'd be up for trying it for sure!



#32 curious_sle

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Posted 12 April 2019 - 04:45 PM

Thank you very much for sharing that! I'll watch it tonight whilst I'm on the dreadmill. :)

I hope it's not too expensive -- I'd be up for trying it for sure!

 

55$ for a one month supply if sold individually and less if on a subscription base is what i recall.



#33 Gayle63

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Posted 12 April 2019 - 04:49 PM

$55 a month is doable. A bit pricey, but I can cut something else out of the old budget, lol. Who needs food anyhow?



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#34 StanG

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Posted 19 April 2019 - 08:21 PM

Everything points to this NOT being as "hoped for". I'd love to see it be true but this hasn't even begun to be tested enough to make such claims


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#35 midas

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Posted 20 April 2019 - 12:32 AM

Everything points to this NOT being as "hoped for". I'd love to see it be true but this hasn't even begun to be tested enough to make such claims

 

Well, it's supposed to be imminent, let's wait and see eh?


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#36 Gayle63

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Posted 20 April 2019 - 01:25 AM

Anybody can get the NAD levels of a 19 year old after 2 weeks.  The big problem is maintaining those levels at 2 months.

Because she's launching a product competitive with other NAD boosting supplements, her dismissal of their benefits is a bit suspect, although I would be willing to try their product. However, another issue is that they only tested it on one guy? That's really no foundation on which to make any sort of claims, IMO.


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#37 Phoebus

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Posted 07 October 2019 - 02:08 PM

Well its finally to market. You can actually buy it now. If anyone here does try it, please let us know what you think 

 

https://nuchido.com/..._eid=9f773e8660



#38 Phoebus

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Posted 07 October 2019 - 02:12 PM

you know something? Now that I can actually see the ingredients...bleh!

 

Vit C, niacin, zinc, green tea, parsley, rutin, black pepper, lipoic acid. 

 

Big f-in deal! You want me to pay $55 for that? Gimme a break with this. 


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#39 MikeDC

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Posted 07 October 2019 - 03:29 PM

Worth a try at $15 per month.

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#40 joesixpack

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Posted 09 October 2019 - 03:05 AM

Worth a try at $15 per month.

 

Not, based on what I saw of the ingredients. Was really hoping for something new.



#41 Gayle63

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Posted 09 October 2019 - 03:24 AM

If anyone thinks that long term NAD+ supplementation is pointless, then i would like to hear how people think about it, who have been taking it for a longer period of time.

 

My experience (after 1 year) is still positive, but maybe that wasn't long enough. 

I have been taking NR for almost five years (five years in Feb. 2020). Now that I'm 56, I believe I am seeing positive results. To me, this is a long-term supplement that may (MAY!) slow aging. I personally think I'm aging more slowly than my peers, based on musculature, immune system, energy levels, etc. I've never been an unhealthy person, so I can't say it cured this or that. To me, it's worth it to keep going with it. I'm curious to try Nuchido, but it seems prudent to wait for more research. Testing on one 57 yr old seems ludicrously inadequate. I started with Basis and have been taking TruNiagen for the last few years.


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#42 Mind

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Posted 09 October 2019 - 11:29 PM

I have been taking it for a few days now. No negative side effects. Mild energy boost, but that is a subjective assessment of course.



#43 izan82

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Posted 10 October 2019 - 05:17 PM

it's a scam


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#44 pamojja

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Posted 10 October 2019 - 07:22 PM

it's a scam

 

The ingredients are fine. Take them since many years. The price for such not at all high quality ingredients is of course a scam.

 10 mg ascorbic acid
250 mg nicotinamide
300 mg alpha lipoic acid
  5 mg zinc

1.1 g Propietary Blend
      green tea leaf extract (~500)
      parsley leaf powder (~400)
      rutin extract (~150)
      black pepper fruit extract (~50)

Edited by pamojja, 10 October 2019 - 07:26 PM.

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#45 p75213

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Posted 12 October 2019 - 07:36 PM

Shouldn't be too difficult to mix up a DIY version of Time+. Although that does seem a lot of green tea extract.
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#46 pamojja

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Posted 13 October 2019 - 10:58 AM

Although that does seem a lot of green tea extract.

 

Not really, if one uses it for chronic disease. I've got about 660mg of green tea extract per day the last 10 years alone. And did experience remission of a walking-disabilty from PAD.

Therefore much more interesting than the Conlon too short case study, would be to test NAD levels in those of us who already took this mixture for 10 years. But I wouldn't know were to get such a test.


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#47 p75213

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Posted 13 October 2019 - 01:03 PM

But in this case we're talking about 1 gram of green tea leaf extract per day. As the dose is 3 capsules twice a day taken 6 hours apart.

#48 Oakman

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Posted 13 October 2019 - 02:12 PM

 

The ingredients are fine. Take them since many years. The price for such not at all high quality ingredients is of course a scam.

 10 mg ascorbic acid
250 mg nicotinamide
300 mg alpha lipoic acid
  5 mg zinc

1.1 g Propietary Blend
      green tea leaf extract (~500)
      parsley leaf powder (~400)
      rutin extract (~150)
      black pepper fruit extract (~50)

I looked at their site for the above info and noticed:

 

1) nowhere do they list the ingredients (unless I missed that). Aren't supplement manufacturers required to do that?

2) they talk a lot about NAD, but entirely generically. They could have lifted most of their info from this forum!

    (pamojja - wondering where did you got the "proprietary blend" amounts listed above - Mind's photo he took of a label did not list them and I didn't see them on the site?)

3) they list three patents for something, but I couldn't find them (that could me just my search issues, but...)

4) they say they have found the molecules that raise NAD+ without and better than precursors, but the statement lacks any studies specifically mentioning these substances, or even any explanation why their product does any of these things.

5) Alivebynature has a product, "AMPK Activator - Boost Endogenous NAD+", with similar intentions, but with different ingredients....with the exception of EGCG . So is that really the supposed 'secret sauce'?

 

As several have mentioned, and I'll include myself here, people have already been taking many (most, all) of the above for considerable periods of time. I'm not saying I don't feel and perform well, and arguably better than ever.  So perhaps we already "discovered" this magic sauce before - accidently - and have been reaping the benefits? Whatever the case, the price for this product is way out of bounds, and I doubt any patent can contain a multitude of copycats should it prove to be the magic combination. I mean, they are all generic substances!


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#49 pamojja

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Posted 13 October 2019 - 04:27 PM

    (pamojja - wondering where did you got the "proprietary blend" amounts listed above - Mind's photo he took of a label did not list them and I didn't see them on the site?)

 

https://www.longecit...ndpost&p=879860 Common sense with propietary blends (which I myself avoid as the plague), which usually list their ingredients in the order of lesser quantities (often obvious in listing most expensive ingredients last). And how much I used myself over the years to have meaningful effects of each of these in myself. My estimates could be +/-100mg though.

 

But in this case we're talking about 1 gram of green tea leaf extract per day.

 

The bottle says seving size is 3 capsules. And the amounts given are for a daily serving size of 3 capsules. Therefore not 1 gram green tea extract, since the whole propiatary blend per day is 1.1 grams in total. Which wouldn't leave any meaningful space for the parsley powder (contains 45mg of Apigenin per 1g), the rutin extract, as well as the black pepper extract.

 


Edited by pamojja, 13 October 2019 - 04:33 PM.


#50 p75213

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Posted 13 October 2019 - 07:30 PM

https://www.longecit...ndpost&p=879860 Common sense with propietary blends (which I myself avoid as the plague), which usually list their ingredients in the order of lesser quantities (often obvious in listing most expensive ingredients last). And how much I used myself over the years to have meaningful effects of each of these in myself. My estimates could be +/-100mg though.


The bottle says seving size is 3 capsules. And the amounts given are for a daily serving size of 3 capsules. Therefore not 1 gram green tea extract, since the whole propiatary blend per day is 1.1 grams in total. Which wouldn't leave any meaningful space for the parsley powder (contains 45mg of Apigenin per 1g), the rutin extract, as well as the black pepper extract.


The directions say 3 capsules twice a day 6 hours apart. Also they warn about exceeding 300 mg EGCG per day.

https://nuchido.co.u...ts/nuchido-time

#51 pamojja

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Posted 13 October 2019 - 08:26 PM

The directions say 3 capsules twice a day 6 hours apart. Also they warn about exceeding 300 mg EGCG per day.

https://nuchido.co.u...ts/nuchido-time

 

I only looked at the picture of the label, and usually serving size is meant for a whole day. But in this case they don't follow this usual convention. They also say 6 caps contain the 300mg EGCG. Since most commercial quality green tea extracts contain 45% EGCG - and assuming they use high quality for that price - it would amount to 667mg of green tea per daily dose of 6 caps. That of course gives more space up to 2.2 g of the total propietary blend. My new estimate:

20 mg ascorbic acid
500 mg nicotinamide
600 mg alpha lipoic acid
10 mg zinc

2.2 g Propietary Blend
      green tea leaf extract (~667, or more less quality extract)
      parsley leaf powder (~633, assuming slightly less than green tea)
      Sophora japonica extract, standardized to Rutin (~600)
      black pepper fruit extract (~300)

Assuming they use any labeling conventions at all, and not try to obfuscate their 'propietary' formula for being protected to be copied from the competition. In my former estimate I just assumed a lowest effective dose fitting nicely with 1.1g. And there sure is a much higher therapeutic range for most of its ingredients, like the parsley powder. Or by using less less quality extracts.

 

 

 



#52 Rays

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Posted 14 October 2019 - 09:16 AM

 

3) they list three patents for something, but I couldn't find them

 

 

 

I found one of their patent applications online. It shows the components in NCD201 on page 26.
 

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#53 Oakman

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Posted 14 October 2019 - 01:37 PM

 

I found one of their patent applications online. It shows the components in NCD201 on page 26.
 

 

 

Good find. It certainly spec a lot of different supplements in this patent. Moreover, it covers a vast range of amounts, and oral, topical, and parenteral uses. I'm frankly surprised Nucido Time has only ALA in common with NCD201 spec'ed in the patent. Strange.

 

Interesting nevertheless.



#54 Gayle63

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Posted 14 October 2019 - 02:36 PM

Another entrant to the market: https://nadovim.com/


Good find. It certainly spec a lot of different supplements in this patent. Moreover, it covers a vast range of amounts, and oral, topical, and parenteral uses. I'm frankly surprised Nucido Time has only ALA in common with NCD201 spec'ed in the patent. Strange.

 

Interesting nevertheless.

Does this mean Nuchido has 1,000 mg of NR per serving? If so, that seems pretty good. But I do wonder why ingredients aren't more easily found on their website.



#55 MikeDC

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Posted 14 October 2019 - 03:26 PM

The study they cited may be conducted with different ingredients than the retail product. The results need to be independently verified.
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#56 Oakman

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Posted 14 October 2019 - 04:01 PM

Another entrant to the market: https://nadovim.com/


Does this mean Nuchido has 1,000 mg of NR per serving? If so, that seems pretty good. But I do wonder why ingredients aren't more easily found on their website.

 

No, the "Time" has zero NR, or anything but the ALA mentioned in the NCD201 formula.


Edited by Oakman, 14 October 2019 - 04:02 PM.

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#57 Gayle63

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Posted 14 October 2019 - 05:20 PM

No, the "Time" has zero NR, or anything but the ALA mentioned in the NCD201 formula.

Ah, okay, thanks!



#58 Phoebus

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Posted 14 October 2019 - 09:08 PM

Shouldn't be too difficult to mix up a DIY version of Time+. Although that does seem a lot of green tea extract.

 

chronic supplementation of GTE is bad for your liver. 

 

You need to take a break from it here and there. 


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#59 p75213

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Posted 14 October 2019 - 10:52 PM

chronic supplementation of GTE is bad for your liver.

You need to take a break from it here and there.

How much is chronic? Time+ is about 660 mg a day.

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