I recently ran across videos (starting Dec 2019) from this young doctor, Brad Stanfield, from New Zealand, who had some interesting thoughts on NA, NMN, and NAM. He looks a bit 'deer in the headlights' in his videos, but what he says, how he explains things, makes more sense to me than, for instance, the ramblings of Dr. Sinclair.
Esp. noteable, he discusses using niacin and a study that shows its ability to raise NAD levels in muscle, something NMN and NR are not capable of doing.
NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open. Here, we report systemic NAD+ deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD+ - booster niacin, a vitamin B3 form (to 750–1,000 mg/day; clinicaltrials.gov NCT03973203) for patients and their matched controls for 10 or 4 months, respectively. Blood NAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidence indicates that blood analysis is useful in identifying NAD+ deficiency and points niacin to be an efficient NAD+ booster for treating mitochondrial myopathy.
https://www.cell.com...4131(20)30190-X
---
NMN vs Nicotinamide & Niacin | How To Save Money April 2020 https://www.youtube....h?v=TViYsaUM8uk
NIACIN & NICOTINAMIDE vs Expensive NR & NMN? https://www.youtube....h?v=6BkduBDpjvk
NIACIN vs NMN | Important May 2020 Research https://www.youtube....y5eK02s0&t=610s
Edited by Oakman, 08 June 2020 - 05:12 PM.