10 replies to this topic

[RichardAlan]

First time I read about using some herbal alternatives to Metformin.  Has anyone any advice to offer on this.  Here's the link that prompted this post:

https://www.lifeexte...ss/ampk/page-01

[brosci]

I often eat a ketogenic diet, spend most of the day fasted, and exercise in this fasted state before breakfast.  I would imagine this activates AMPK at least as much as some small amount of an herb in a capsule.

Edited by brosci, 01 December 2018 - 06:29 AM.

[Blueflash]

Berberine would be another. It can interfere with pharmaceuticals however. More info at examine.  com

[Kimer Med]

Glucosamine and Resveratrol also stimulate AMPK.

 

https://www.ncbi.nlm...pubmed/19520133

https://www.ncbi.nlm...les/PMC3545644/

 

[Kodiak]

I believe I've read that forskolin induces AMPK activation as well. 

 

[Kimer Med]

I believe I've read that forskolin induces AMPK activation as well. 

 

Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells

https://www.ncbi.nlm...pubmed/18950855

[Benko]

Can Botanicals Replace Metformin?

Posted on October 13, 2015

Gymnema, Jiaogulan and Berberine: Can herbs replace metformin?

 

https://joshmitteldo...lace-metformin/

[Skyguy2005]

I believe Ginkgo Biloba is fairly good at activating AMPK.

 

https://www.hindawi....am/2015/298635/ ( Ginkgolide C activates AMPK)

https://www.scienced...319016418301452 ( Ginkgolide C activates SIRT1/AMPK)

Edited by Skyguy2005, 31 January 2019 - 09:49 PM.

[Ames]

I like sulforaphane. Though, consider only taking it once every 2-3 days until you get used to its blood sugar lowering effect. In fact, continuous staggered use may be preferrable to realize a therapeutic effect in my experience. But test different schedules.

 

https://pubmed.ncbi....h.gov/32940670/

Edited by Ames, 22 January 2022 - 12:10 AM.

[johnhemming]

Brad Stanfield has done a video comparing Metformin and Berberine.   

 

I am one for Berberine notwithstanding his video.

[syr_]

I'm researching Icariin (the main active flavonol glycoside isolated from the herb Epimedium pubescens) for other purposes and I have encountered a study where it was compared to metformin (in rats). It seems relatively similar in action. while not being anti-androgenic.

Some refs:

 

Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome in rats (nih.gov)

Frontiers | Icariin Inhibits AMPK-Dependent Autophagy and Adipogenesis in Adipocytes In vitro and in a Model of Graves' Orbitopathy In vivo | Physiology (frontiersin.org)

AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice | SpringerLink