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3,3-Dimethyl-1-butanol (choline analogue) as a TMAO inhibitor

tmao gut choline diet carnitine atherosclerosis tma microbiome

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#1 MankindRising

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Posted 06 December 2018 - 12:01 AM

Just came accross this and its present in olive oil for example (not sure in what quantities though yet).

Any unexplored potential in this? and thoughts on this compounds possibly contributing to the health effects of mediterranean diet (which is obviously rich in olive oil)




3,3-Dimethyl-1-butanol 200px-3%2C3-Dimethyl-1-butanol.svg.png


3,3-Dimethyl-1-butanol (DMB) is a structural analog of choline.[1]



DMB inhibits microbial trimethylamine (TMA) formation in mice and in human feces, thereby reducing plasma trimethylamine N-oxide (TMAO) levels after choline or carnitine supplementation.[1] It consequently inhibited choline-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in mice without alterations in circulating cholesterol levels.[1]

While mice placed on a choline supplemented diet showed an increase in the proportions of the bacterial taxon Clostridiales in the gut, DMB induced a decrease in the proportions of this taxon.[1]

Mice showed no evidence of toxicity to chronic (16-week) DMB exposure.[1]



DMB is found in some balsamic vinegars, red wines, and some cold-pressed extra virgin olive oils and grapeseed oils.[1]"

Edited by MankindRising, 06 December 2018 - 12:03 AM.

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#2 Daniel Cooper

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Posted 15 April 2019 - 03:20 PM

This seems like an important finding.  As you stated, it would be nice to know what quantities are available in various sources.





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Also tagged with one or more of these keywords: tmao, gut, choline, diet, carnitine, atherosclerosis, tma, microbiome

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