Does your dose of NMN depend on how much e...
RichardAlan 08 Dec 2018
I usually walk around 7-10 miles a day and am wondering about what dose of NMN to take. I read some people change the dose depending on how much they exercise. With my 7-10 miles / day should I be changing my dose or leave constant at the same amount of say 500mg / day?
able 08 Dec 2018
I believe most of us who vary our dosage are trying to avoid homeostasis - the body adjusting to the external supplementation and lowering its own production, or excreting more of the external dose.
Some of the studies with NR show 1,000 mg a day resulting in an initial increase in NAD, that then drops down quite a bit in month 2 and beyond.
With that in mind, cycling your dosage may be helpful to avoid the homeostasis. Or not - no-one really knows.
It does seem to help exercise capacity, and makes sense to me that if cycling, it would be best to do more on days you exercise.
Personally, I take a lot on the 3 days a week I exercise intensely (HIIT). Other days, I might take a scoop in the morning to help me wake up, but nothing more, and none on weekends.
Oakman 10 Dec 2018
^ I second able's opinion, and agree specifically with "No one really knows". Also, there's the financial aspect, supplements like NMN, NR, NAD+ aren't inexpensive, i.e., high dosing costs a lot on a continuous basis, esp. if you use several.
bluemoon 13 Dec 2018
Some of the studies with NR show 1,000 mg a day resulting in an initial increase in NAD, that then drops down quite a bit in month 2 and beyond.
The Chromadex study on the TruNiagen website shows a sustained level of NAD+ increase over several weeks. The U of Colorado study doesn't show a drop after six weeks at 1000 mg either. Elysium Basis' 500 mg dose does show a drop after four weeks. Can you link to the 1,000 mg studies that show a decline?
able 15 Dec 2018
The Chromadex study on the TruNiagen website shows a sustained level of NAD+ increase over several weeks. The U of Colorado study doesn't show a drop after six weeks at 1000 mg either. Elysium Basis' 500 mg dose does show a drop after four weeks. Can you link to the 1,000 mg studies that show a decline?
Ah, my mistake. I was mostly thinking of the Elysium study that showed drop from 60% to 40-50% after 4 weeks, but was at 500 Mg per day.
The other 1,000 mg I was thinking of was Dr Brenner himself in the Trammel thesis, showed a drop at the end of his 7 day usage, but that was N=1 and really meaningless.
The U of Colorado only published the single data point at 6 weeks, showing 60% increase, so we don't know if that is stable or not.
I am interested to see the Chromadex study when they publish. It is encouraging that they show sustained NAD+ increase over 8 weeks at 1,000 mg. Perhaps that is more effective than 500 mg.