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Transplanting bone marrow of young mice into old mice prevented dementia preserved memory and learning abilities

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#1 Phoebus

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Posted 21 February 2019 - 04:48 PM


 

PUBLIC RELEASE: 

20-FEB-2019 Young bone marrow rejuvenates aging mouse brains, study finds

Transplanting marrow from young lab mice to old mice preserves memory and learning skills

CEDARS-SINAI MEDICAL CENTER

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IMAGE: MICROGLIA IN BRAINS OF OLD MICE HAVE LARGER CELL BODIES WITH FEWER AND SHORTER BRANCHES THAN THOSE IN YOUNG MICE. BUT MICROGLIA OF OLD MICE WHO RECEIVED BONE MARROW TRANSPLANTS... view more 

CREDIT: CEDARS-SINAI / COMMUNICATIONS BIOLOGY

LOS ANGELES (EMBARGOED UNTIL 5:00 A.M. EST ON FEB. 20, 2019) -- A new study has found that transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. The findings support an emerging model that attributes cognitive decline, in part, to aging of blood cells, which are produced in bone marrow.

"While prior studies have shown that introducing blood from young mice can reverse cognitive decline in old mice, it is not well understood how this happens," said Helen Goodridge, PhD, associate professor of Medicine and Biomedical Sciences at Cedars-Sinai and co-senior author of the study. "Our research suggests one answer lies in specific properties of youthful blood cells."

 

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https://eurekalert.o...c-ybm021919.php






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