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sigma 1 agonist and DHEA biphasic response

5ht regulation. sigma 1 nmda glutamatergic signaling serotonergic signaling biphasic response pharmacology sigma 1 agonist neurosteroids dhea

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#1 neurobliss

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Posted 24 May 2019 - 09:57 PM

I've been getting really into sigma 1 agonists. It seems to explain a lot of of what I've observed about myself over the years. Sigma chaperone receptors regulate intracellular calcium release, protect endoplasmic reticulum from stress, act as signal transduction amplifiers and regulate lipid rafts and regulate virtually every other neurotransmitter in the body, especially NMDA transduction. All in all, very promising and exciting stuff. 


The easiest sigma agonists for me to experiment with are endogenous neurosteroids DHEA and progesterone.

DHEA is a sigma 1 agonist, progesterone is antagonist. The DHEA part however is tricky because the articles I found say that it has a biphasic response and up to a certain low dose it will act as an agonist and then it becomes competitive antagonist. But I'm left in the dark as to what that maximum dose that might be.


Does anyone happen to either have some knowledge of that or perhaps might be willing to make a guess based on personal experience?

Also tagged with one or more of these keywords: 5ht regulation., sigma 1, nmda, glutamatergic signaling, serotonergic signaling, biphasic response, pharmacology, sigma 1 agonist, neurosteroids, dhea

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