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Cataracts - Increasing Lanosterol Synthase?

lanosterol lanosterol synthase cataracts

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#1 Daniel Cooper

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Posted 27 June 2019 - 02:22 PM


Is anyone aware of anything that will upregulate lanosterol synthase expression?

 

I'm fighting an early onset cataract and decreased lanosterol production is implicated in these things.  I've been working on reducing my cholesterol numbers (I'm at 143 total, not using statins) and this seems to have started about the same time I created a ~40 point drop in cholesterol through diet and exercise.

 

I'd like to keep my plasma cholesterol where it is due to a predisposition to cardiovascular disease.  But, if I could shift some of that cholesterol towards lanosterol that might be useful.  Some topical means of upregulating lanosterol in the eye would probably be a grand idea too.  

 

I've started lanosterol, n-acetylcarnosine and visomitin, eye drops as well, but increasing endogenous lanosterol production in the eye would be most effective I think.

 

 



#2 FrankEd

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Posted 27 June 2019 - 04:19 PM

If you don´t mind would you please describe which lanosterol eye drops are you using?



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#3 Daniel Cooper

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Posted 27 June 2019 - 05:26 PM

If you don´t mind would you please describe which lanosterol eye drops are you using?

 
 
Certainly - it's this:  LanoMax Lanosterol Eye Drops


Since the FDA hasn't approved lanosterol eye drops for humans, this is for pets. It's lanosterol which uses a cyclodextrin carrier to get around lanosterol's poor solubility.

Some people say it works for Spot and Fido, so maybe it works on humans as well. Who knows. Since lanosterol is endogenous to humans, particularly in the eye, and cyclodextrin is used in other eye drop formulations for humans, I'm not terribly concerned about it being harmful, except perhaps to my wallet.  Lanomax says that their drops are safe for humans, but they are not sold for human use.  
 
The evidence seems reasonably conclusive that if you can get lanosterol to the lens that it will very likely prevent and reverse cataracts, the issue has been actually getting it in there.  The lens capsule is a highly protected environment immunologically so it's not a slam dunk getting any substance in there.
 
Raising endogenous lanosterol levels in the eye would clearly be beneficial, hence the topic of this thread.
 
My goal is at a minimum to stave off the progression of these cataracts for 3 or 4 years till I can go to Canada and get these IOL implants:
 
Ocumetics Bionic Lens

 

Unfortunately at the rate it's currently progressing I'm not going to make it till those implants are approved and you can't go back and revise an existing implant with that IOL.

 

 



#4 FrankEd

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Posted 27 June 2019 - 08:29 PM

Thanks a lot Daniel, I have 10% cataract in both eyes and it´s very annoying. Unfortunately I can´t get Visomitin because it´s too hot in my country and I don´t know if

it will survive a trip from Russia.

 

Do you have some improvement with Visomitin?



#5 Daniel Cooper

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Posted 27 June 2019 - 09:19 PM

I've only been doing this regimen a little under 2 weeks now.  Too early to tell.

 

 



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#6 nickdino

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Posted 09 August 2019 - 09:19 AM

Hi Daniel, would you please keep us informed about your experiences with these drops your taking?

I've tried visomitin for some months but it didnt reverse cataract formation..





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