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Mitophagy inhibited by PUM2

mitochondria mitophagy pum2

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#1 smithx

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Posted 26 July 2019 - 08:18 PM


These researchers were able to reverse mitochondrial dysfunction in old cells by CRISPR inhibition of PUM2.
 

PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in ribonucleoprotein particles (RNP). Consequently, PUM2 prevents Mff translation, impairing mitochondrial fission and mitophagy thereby leading to mitochondrial dysfunction

 

https://actu.epfl.ch...to-fight-aging/

 

This begs the question of whether there's another way to either inhibit PUM2 or increase Mff via small molecules (supplements).

 

Anyone have any insights?

 

 


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#2 smithx

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Posted 27 July 2019 - 12:06 AM

Interesting:

https://design.synth...917&symbol=PUM2



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