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246 Years of longevity from one ethynyl fluororapamycin depot injection

rapamycin mtor fluorine halogen ethynyl

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#1 treonsverdery

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Posted 30 August 2019 - 01:13 AM


I thought of a longevity drug that some upper 1% of rich person person could make for $

 

246 years from one gram of a new ethynyl fluororapamycin:

 

One gram from a time release depot dose (like a norplant, nexplanon implanon or a better palmitate),

 

Halogenated chemicals are sometimes 1000 more active at a particular mg/dose

 

Ethynylized molecules are sometimes 8 times more active at a particular mg/dose

 

89 mg/24 hours of rapamycin is like the same dose that makes mice live 60% longer as a human dose

 

1 gram of depot dose of a longevity drug like rapamycin is 89,887.6 doses, divided with 365 is 264 years of activity.

 

To do the research a person could test 16 mice each, at 1862 days each, at $.5 per mouse per 24 hours is $15,892 for all the mice for 5.1 years of study, including the chemicals, on each mouse.

 

If each of 10 molecular variants of ethynylized fluororapamycin is tested then that is $158,920 to test all ten variants on mice.  At $10,000 to synthesize a gram of each tested ethynyl fluororapamycin variant, 1 gram per mouse is sufficient, so that is $10,000 to make the tested drugs.

 

So, about 3.3 million US citizens could sponsor this children, and make a new longevity drug, just one dose of which during their lifespan could make them live 60% or longer.  Among the millions that love their children they could bring them a tremendous benefit. This is a gift of longevity escape velocity to the plausibly 14 millions of the the loved ones of the 1% of the US rich.  Tell the rich, and tell all the other people too.


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#2 Kentavr

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Posted 20 September 2019 - 08:21 PM

I am a chemist and, believe me: almost everything that is associated with fluorine in biologically active substances ultimately is poisonous.

Fluoride in such compounds is very dangerous.
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#3 Turnbuckle

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Posted 20 September 2019 - 10:55 PM

More of a halfbakery idea than a serious one.


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#4 Daniel Cooper

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Posted 03 October 2019 - 02:14 PM

Why on earth would you think this would work?

 

There are multiple pathways of aging.  Let's say your super rapamycin actually works and completely halts whatever aging pathway rapamycin works against.

 

Now what?  Well, the next pathway down now becomes the long pole in the tent.  You're talking about a threefold increase in human lifespan. There's no way working on any one single aging mechanism is going to yield that sort of improvement.  No one has ever seen that degree of lifespan improvement even in short lived mammals like rats and mice, and their lifespans are far easier to increase compared to a human which is already relatively optimized for long life.

 

 

 







Also tagged with one or more of these keywords: rapamycin, mtor, fluorine, halogen, ethynyl

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