• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Any Thoughts on this Fasting Mimic: Humanin?

peptide fasting mimic

  • Please log in to reply
No replies to this topic
⌛⇒ MITOMOUSE has been fully funded!

#1 Automail

  • Guest
  • 23 posts
  • 4
  • Location:sheol, afterlife

Posted 09 October 2019 - 02:48 PM


Humanin (HNG)-induced suppression of IGF-1 mimicked the homeostatic conditions created by caloric restriction or fasting in the host suggesting that HNG may be a caloric-restriction mimetic with a promising therapeutic potential for patients with cancer. The laboratory is currently pursuing the studies of humanin action on body and tumor metabolism. It functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HNG improved insulin sensitivity in models of diabetes.

Using state of the art clamp technology, researchers examined the role of central and peripheral HN on insulin action. Continuous infusion of HNG intra-cerebro-ventricularly significantly improved overall insulin sensitivity.

They also determined that the amount of detectable HNG in hypothalamus, skeletal muscle, and cortex decreased with age in rodents, circulating levels of HN were decreased with age in humans and mice, and even suggesting that HNG works through the regulation of IRS-1/mTOR insulin signaling in the hippocampus, HNG increases the activity of autophagy and decreases Aβ deposition in the brain, and improves learning ability and memory of AD mice.

 

https://www.ncbi.nlm...les/PMC2709436/

https://www.ncbi.nlm...les/PMC4873641/

https://academic.oup...12/4511/2422742

https://www.ncbi.nlm...pubmed/29058763







Also tagged with one or more of these keywords: peptide, fasting, mimic

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users