9 replies to this topic

[Andrew70]

Hello:

 

I just I have discovered this company PatchMD that sells patches with vitamins. In particular I like it:

 

https://www.patchmd....ical-Patch.html

 

What do you think about it?

 

Regards.

 

Andrew

[Andrew70]

Someone has rated it as "Pointless, Timewasting". I absolutely disagree. If there is another way to take the supplements, it is well worth to know.

 

So, if somebody has something good or bad to tell about this method or company, be welcome to share with us.

[Daniel Cooper]

I seriously question how much of these compounds are they able to deliver transdermally.  Most vitamins and supplements are not dosed in micrograms.  A typical dose is in the range of 10s to 100s of milligrams.  It's not important how much of each compound is in each patch, but rather how much makes it across the dermal barrier and is delivered effectively.  If they have data on that I'd love to see it.

 

Also, some of those compounds are readily available orally (like vitamin C).  I just don't see any point in dosing them transdermally.

 

 

 

 

 

[Andrew70]

I seriously question how much of these compounds are they able to deliver transdermally.  Most vitamins and supplements are not dosed in micrograms.  A typical dose is in the range of 10s to 100s of milligrams.  It's not important how much of each compound is in each patch, but rather how much makes it across the dermal barrier and is delivered effectively.  If they have data on that I'd love to see it.

 

Also, some of those compounds are readily available orally (like vitamin C).  I just don't see any point in dosing them transdermally.

 

I think it is a good point if it means to avoid the intake of 8 to 12 different vitamins or supplements. It could be easy to have all the entire lot of supplements in a single patch a day.

 

About how much is it absorb, I think it is pretty steady the amount, since other drugs are administered that way under a medical point of view.

 

I will investigate more and inform this thread.

[Daniel Cooper]

I think you are missing the reason for my skepticism.

 

Systemic drugs (as opposed to local drugs like a lidocaine patch) that are administered via transdermal patch, for example fentanyl, typically have very low effective doses.  Fentanyl for instance come in doses of 12 to 75 micrograms.

 

I am just very skeptical that you're going to move 100's of milligrams of any of these compounds across the skin which is designed to be relatively impermeable such that they go systemic.  That's a lot of material you're trying to move across the dermal barrier. 

 

Yeah, nice idea to slap a patch on instead of taking a half dozen pills, but if it doesn't work, it doesn't work.

 

I'm certainly open to evidence to the contrary.  Perhaps the manufacturer of that patch has some data on plasma levels achieved of these compounds via their patch delivery system.  Absent that, I wouldn't spend money on something that isn't even proven to get these supplements into your system.

 

 

[orion22]

in 1 word:garbajeeeeeeeeeeeeeeeeeeeeeeee 

[Andrew70]

I think you are missing the reason for my skepticism.

 

Systemic drugs (as opposed to local drugs like a lidocaine patch) that are administered via transdermal patch, for example fentanyl, typically have very low effective doses.  Fentanyl for instance come in doses of 12 to 75 micrograms.

 

I am just very skeptical that you're going to move 100's of milligrams of any of these compounds across the skin which is designed to be relatively impermeable such that they go systemic.  That's a lot of material you're trying to move across the dermal barrier. 

 

Yeah, nice idea to slap a patch on instead of taking a half dozen pills, but if it doesn't work, it doesn't work.

 

I'm certainly open to evidence to the contrary.  Perhaps the manufacturer of that patch has some data on plasma levels achieved of these compounds via their patch delivery system.  Absent that, I wouldn't spend money on something that isn't even proven to get these supplements into your system.

 

I understand but do not share your point.

 

In this websites it is explain something about it.

 

https://www.ncbi.nlm...les/PMC4695828/

 

https://en.wikipedia...ansdermal_patch " they are only useful for fat-soluble and relatively small molecular weight drugs, possibly to pass through the cornea layer"

 

Despite missing some technical information about how works those patches and others similar, I found out many and more and more drugs are available by via transdermical. Possibly very soon we will be using them instead of pills (also have a lot of disadvantages if not so many yet).

 

I will keep looking for this interesting method.

[Andrew70]

in 1 word:garbajeeeeeeeeeeeeeeeeeeeeeeee 

 

May be it will not word yet or not with all the supplements we would wish to, but some patches works (see below, if you do not mind).

 

Pitifully, the only garbage is your reply, empty, lack of effort to justify and careless.

 

Popular uses

• The highest selling transdermal patch in the United States of America is the nicotine patch, which releases nicotine in controlled doses to help with cessation of tobacco smoking. The first commercially available vapour patch to reduce smoking was approved in Europe in 2007.
• Two opioid medications used to provide round-the-clock relief for severe pain are often prescribed in patch form, fentanyl CII (marketed as Duragesic) and buprenorphine CIII (marketed as BuTrans).
• Hormonal patches
  • estrogen patches are sometimes prescribed to treat menopausal symptoms (as well as post-menopausal osteoporosis) and to transgender women as a type of hormone replacement therapy.
  • contraceptive patch (marketed as Ortho Evra or Evra) and
  • testosterone CIII patches for both men (Androde) and women (Intrinsa).
• Nitroglycerin patches are sometimes prescribed for the treatment of angina in lieu of sublingual pills.
• Transdermal scopolamine is commonly used as a treatment for motion sickness.^[3]
• The anti-hypertensive drug clonidine is available in transdermal patch form^[4]
• Emsam, a transdermal form of the MAOI selegiline, became the first transdermal delivery agent for an antidepressant approved for use in the U.S. in March 2006.^[5]
• Daytrana, the first methylphenidate transdermal delivery system for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), was approved by the FDA in April 2006.^[6]
• Vitamin B12 may also be administered through a transdermal patch. Cyanocobalamin, a highly stable form of vitamin B12, is compatible with transdermal patching.^[7]
• 5-Hydroxytryptophan (5-HTP) can also be administered through a transdermal patch, which was launched in the United Kingdom in early 2014.^[8]
• Rivastigmine, an Alzheimer's treatment medication, was released in patch form in 2007, under the brand name Exelon^[9]

 

[orion22]

so you advertise for this website? sorry that for time wasted on my 1 word 

yea i can t say anything bad about the work of others and it is good work  but what i meant is  compared to other choices and price/what you get  it ranks very low we can t give medals for "7th place" thats the reality mate 

[Andrew70]

so you advertise for this website? sorry that for time wasted on my 1 word 

yea i can t say anything bad about the work of others and it is good work  but what i meant is  compared to other choices and price/what you get  it ranks very low we can t give medals for "7th place" thats the reality mate 

 

I do not advertise... if it is all you can see...