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NAD+ in Brain Aging and Neurodegenerative Disorders

nad brain aging

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#1 Iporuru

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Posted 14 November 2019 - 07:23 PM


 
NAD + is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD +-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD + and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD +-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

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#2 Iporuru

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Posted 14 November 2019 - 07:36 PM

The probable connections between NAD and Alzheimer’s, Parkinson’s, ALS, and Huntington’s diseases are explained in this figure.

 

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#3 joesixpack

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Posted 15 November 2019 - 04:05 AM

Yes, what is your point?


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#4 ambivalent

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Posted 06 December 2019 - 04:31 PM

There was some reporting of positive effects of NR on a neurodegenerative disorders a couple of years ago:

 

https://www.longecit...e-4#entry833268

 

 



#5 MikeDC

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Posted 12 December 2019 - 01:07 PM

One study of NR on cognitive impairment and sleep quality will be published soon.

#6 Tam

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Posted 17 December 2019 - 03:49 PM

I am a caregiver for someone with symptoms of ALS (no diagnosis at this time).

 

One of the hallmarks of ALS is that it is easy to lose weight, and very difficult or even impossible to gain weight.

 

Statistically, persons with ALS (PALS) have a better life expectancy if they are a little overweight rather than normal weight.

 

Having read/scanned the 20-page thread dedicated to personal experience with NMN, it seems that many people report rapid and effortless weight loss. Of course, this is desirable for many people.

 

My question is: Is there any experience or information regarding a situation in which the person does not want to lose weight, and actually wants to gain weight instead, including both muscle and fat?

 

Thanks!



#7 bluemoon

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Posted 17 December 2019 - 07:03 PM

One study of NR on cognitive impairment and sleep quality will be published soon.

 

That Chromadex study was completed in April so won't be published until 2021. Not exactly "soon."



#8 MikeDC

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Posted 17 December 2019 - 07:05 PM

That Chromadex study was completed in April so won't be published until 2021. Not exactly "soon."


Just because their last clinical trial took two year to publish, it doesn’t mean this one will take that long. Normally 10 month is enough time.

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#9 bluemoon

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Posted 17 December 2019 - 11:03 PM

Just because their last clinical trial took two year to publish, it doesn’t mean this one will take that long. Normally 10 month is enough time.

 

So far, Elysium has been the fastest to publish at 15 months so there is no reason to think Chrmadex will be 10 months after 24 month lag periods.

We can expect those results sometime between next August and April 2021, neither of which are soon. 



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