I have Pramipexole which works on the rest of the dopamine receptors, but is there a drug that you can get relatively easy and with a decent half-life that work on D1 and D5?
Here are the stats for Prami:
- D2S receptor (Ki = 3.9 nM; IA = 130%)
- D2L receptor (Ki = 2.2 nM; IA = 70%)
- D3 receptor (Ki = 0.5 nM; IA = 70%)
- D4 receptor (Ki = 5.1 nM; IA = 42%)
can you just increase the dosage to get more percentage/activation on each receptor or does it not work that way? For example it only has 42% binding on D4 receptor which seems weak.
Edited by farshad, 29 November 2019 - 05:46 AM.