This particular research had been very briefly discussed before, but not in a dedicated thread -it merely came up as one of the features of Rapamycin
https://www.ncbi.nlm...les/PMC4008417/
However, this is extremely impressive. After just a single administration of Rapamycin, the bodyweight of rats was permanently reduced . The animals were not followed up till their death, so how long this effect would last in unclear. However results are long lasting at the very least.
In other words, the bodyweight set-point was lowered.
Another unknown is whether a low dose (like you'd use for longevity purposes) would achieve the same effect.
Since we got a number of people using Rapa, I was wondering if anyone has achieved permanent or long-lasting weight reduction from it. Please also mention your dosing scheme if you did.
Thanks