34 replies to this topic

[chickenscratch]

What spermidine supplement do you take?

[brundall]

What spermidine supplement do you take?

 

DoNotAge

[forever freedom]

 

Another update, some removals and some newish additions

 

Male, aged 53

 

 

On waking 

 

A scoop of Collagen Peptides, one tablespoon Cacao and 2.5 grams Creatine in a black coffee

 

 

With breakfast

 

Zinc Picolinate 15 mg

Nicotinamide Riboside 350 mg

Urolithin A 250 mg

Ubiquinol 100 mg

Hyaluronic acid 200 mg

Alpha Ketoglutaric acid 300 mg

Fish Oil 1000 mg (685mg EPA 310mg DHA)

N-Acetyl Cysteine 600 mg

 

Dinner

 

Fish Oil 1000 mg (685mg EPA 310mg DHA)

Vitamin D3 2000iu 

Tocotrienols 125mg (Delta & Gamma)

Vitamin K2 90mg

Lycopene 15 mg

Lutein 20mg & Zeaxanthin 4mg

Astaxanthin 6 mg

Alpha Ketoglutaric acid 300mg

Spermidine 8mg

Urolithin A 250 mg

Apigenin 50mg

 

Night

 

Magnesium Glycinate 200mg

Glycine 1000mg

Probiotic (20 strains, 65 billion CFU's)

 

 

 

Nice stack, similar to my own. Why don't you add senolytics to it such as quercetin or better yet fisetin?

 

And what about metformin/acarbose?

 

Additionally, why did you stop taking Rutin?

Edited by forever freedom, 28 April 2023 - 01:03 PM.

[brundall]

Nice stack, similar to my own. Why don't you add senolytics to it such as quercetin or better yet fisetin?

 

And what about metformin/acarbose?

 

Additionally, why did you stop taking Rutin?

 

 

 

I am considering senolytics - but just haven't got around to the research yet.

 

I have no idea if Metformin is a good idea or not? and I stopped Rutin due to some tendon soreness every time I took it

 

 

 

I added an Ergothioneine supplement, Whey protein isolate, a multivitamin and a sublingual B12 (due to lowish blood test levels). Also doubled my NAC intake to 1200 mg per day

 

Male, aged 53

 

 

On waking 

 

A scoop of Collagen Peptides, one tablespoon Cacao and 2.5 grams Creatine in a black coffee

 

 

With breakfast

 

Zinc Picolinate 15 mg

Nicotinamide Riboside 350 mg

Urolithin A 250 mg

Ubiquinol 100 mg

Hyaluronic acid 200 mg

Alpha Ketoglutaric acid 300 mg

Fish Oil 1000 mg (685mg EPA 310mg DHA)

N-Acetyl Cysteine 600 mg

Multivitamin

 

Lunch

 

Whey protein isolate

Sublingual B12 Methylcobalamin

 

Dinner

 

Fish Oil 1000 mg (685mg EPA 310mg DHA)

Vitamin D3 2000iu 

Tocotrienols 125mg (Delta & Gamma)

Vitamin K2 90mg

Lycopene 15 mg

Lutein 20mg & Zeaxanthin 4mg

Astaxanthin 6 mg

Alpha Ketoglutaric acid 300mg

Spermidine 8mg

Urolithin A 250 mg

Apigenin (Liposomal) 50mg

Ergothioneine 5mg

 

Night

 

Magnesium Glycinate 200mg

Glycine 1000mg

NAC 600mg

Probiotic (20 strains, 65 billion CFU's)

[LiveWellLiveLong]

You can get that 50mg quercetin with an inconsequential amount of dried parsley I think?  1-2 tablespoons? I think 1g of dried parsley has like 40-50mg apigenin which is so much cheaper of a route to go than the supplements online.

 

 

 

RE Taurine  (Needs references, but I haven't got time. These are easy to verify with Google)

• Taurine inhibits PARP-1
• Excessive PARP-1 uses up cytosolic NAD+.
• Inhibiting PARP-1 can restore cytosolic NAD+ with amazing immediate benefits
• But PARP-1 participates in DNA repair
• Inhibiting PARP-1 with Taurine will reduce DNA repair.
• DNA repair is one of the main activities of cells occurring many times per second
• When DNA repair lags behind DNA damage, the DNA damage will accumulate
• I will not personally inhibit PARP on purpose (Rutin also inhibits PARP)
• Taking TRU Niagen and Grape Seed Extract likely has your cytosolic NAD+ levels good without Taurine

Re Apigenin

• Nuclear CD38 is the main consumer of nuclear NAD+ in old age
• Apigenin with Quercetin inhibits nuclear CD38 and will restore nucNAD+ in old age
• Without nuclear NAD+ there is no benefit from boosting SIRT1
• Apigenin 50mg/day will build up to a steady state level of about 300mg due to its long half life. This is sufficient
• Quercetin inhibits DNA polymerases (POLS) which are used to make DNA & RNA. 
• Quercetin has a very short half life. So taken once daily in normal dose (250-500mg) it will not inhibit POLS very long. However I would not take it multiple times per day