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Memantine & Black seed oil - together

nmda

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#1 DereckLivinNH

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Posted 06 March 2020 - 02:49 AM


Is it okay to take it together?  

 

I know memantine is a NMDA antagonist.  I really dont know the M.o.A. of BSO.  I am honestly guessing no?  I don't have reasoning behind this though. 


Edited by DereckLivinNH, 06 March 2020 - 03:00 AM.


#2 i_know_nothing

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Posted 11 May 2020 - 03:44 PM

No. This is inadvisable. BSO (through Thymoquinone) is an acetylcholinestrase inhibitor. This combination has been shown to be neurotoxic (in rats) : https://www.ncbi.nlm...pubmed/17112636

 

https://www.nature.c...rticles/4000912

https://www.ncbi.nlm...les/PMC4884225/

https://www.ncbi.nlm...les/PMC5002349/



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