1 votes
Posted 09 June 2006 - 10:34 AM
I'm not saying its something to explicitly avoid, or that it can't provide some limited benefit, but I don't think endogenous antioxidants are going to do anything dramatic for us, especially with regard to max LS (the holy grail).
Posted 11 June 2006 - 06:42 PM
Nice work Funk.
So you cap your ALCAR and RLA? Can you take these in powdered form?
Posted 12 June 2006 - 05:56 AM
Posted 12 June 2006 - 03:14 PM
Yes, I'm trying to treat aging (prevention of glycation and cross-linked proteins).Hey Funk, why so much taurine? Are you treating a specific condition?
Acta Physiol Scand. 2004 Jul;181(3):297-303.
Stimulation of glucose utilization and inhibition of protein glycation and AGE products by taurine.
Nandhini AT, Thirunavukkarasu V, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Tamil Nadu, India.
AIM: Pathological effects of the process of non-enzymatic glycation of proteins are reflected in chronic complications of diabetes mellitus. We investigated the antiglycating effect of taurine in high fructose fed rats in vivo and the inhibiting potency of taurine in the process of in vitro glycation. Additionally, we investigated whether taurine enhances glucose utilization in the rat diaphragm. METHODS: Rats fed a high fructose diet (60% total calories) were provided 2% taurine solution for 30 days. The effects of taurine on plasma glucose, fructosamine, protein glycation and glycosylated haemoglobin in high fructose rats were determined. For in vitro glycation a mixture of 25 mm glucose and 25 mm fructose was used as glycating agent, bovine serum albumin as the model protein and taurine as the inhibitor. Incubations were carried out in a constant temperature bath at 37 degrees C for 3-30 days. Amadori products and advanced glycation end products (AGEs) formed were measured. In vitro utilization of glucose was carried out in the rat diaphragm in the presence and absence of insulin in which taurine was used as an additive. RESULTS: The contents of glucose, glycated protein, glycosylated haemoglobin and fructosamine were significantly lowered by taurine treatment to high fructose rats. Taurine prevented in vitro glycation and the accumulation of AGEs. Furthermore, taurine enhanced glucose utilization in the rat diaphragm. This effect was additive to that of insulin and did not interfere with the action of insulin. CONCLUSIONS: These results underline the potential use of taurine as a therapeutic supplement for the prevention of diabetic pathology.
PMID: 16112507 [PubMed - in process]
J Diabetes Complications. 2005 Sep-Oct;19(5):305-11.
Taurine prevents fructose-diet induced collagen abnormalities in rat skin.
Nandhini TA, Thirunavukkarasu V, Ravichandran MK, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608002, India.
OBJECTIVE: The aim of the study is to investigate the effect of taurine administration on the content and characteristics of skin collagen in high-fructose-fed rats. RESEARCH DESIGN AND METHODS: Adult male Wistar rats were divided into four groups of six each: a control group (CON) and a taurine-supplemented control group (CON+TAU), a high fructose diet-fed group (FRU), and a taurine supplemented fructose diet-fed group (FRU+TAU). After 30 days, collagen was isolated from the skin, and its physicochemical properties were studied. RESULTS: Fructose administration caused an accumulation of collagen and extensive cross-linking. This was evidenced by increases in glycation, fluorescence, and peroxidation in collagen samples. The physicochemical properties of collagen, like shrinkage temperature, aldehyde content, solubility pattern, and susceptibility to denaturing agents, were altered in the fructose-fed rats. The sodium dodecyl sulphate-polyacrylamide gel electrophoretic (SDS-PAGE) pattern of collagen from fructose-fed rats showed and elevated beta component of Type I collagen. Simultaneous administration of taurine alleviated these changes. CONCLUSION: The positive influence of taurine on both collagen content and its properties suggests a potential mechanism for the ability of taurine to delay diabetic complications.
PMID: 15196090 [PubMed - indexed for MEDLINE]
1: Clin Chim Acta. 2006 Apr;366(1-2):190-5. Epub 2005 Dec 1. Related Articles, Links
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Effect of lipid peroxides and antioxidants on glycation of hemoglobin: an in vitro study on human erythrocytes.
Selvaraj N, Bobby Z, Sathiyapriya V.
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605 006, India.
BACKGROUND: Glycation and lipid peroxidation are two important processes known to play a key role in complications of many pathophysiological process. We sought to assess the possibility of an interaction between these processes in vitro and to examine the effect of lipoic acid and taurine on the glycation of hemoglobin and lipid peroxidation. METHODS: Human erythrocytes in phosphate buffered saline (pH 7.4) were incubated with 5 or 50 mmol/l glucose. To study the effect of antioxidants on glycation of hemoglobin, erythrocytes were incubated with either lipoic acid or taurine and then exposed to glucose concentration of either 5 or 50 mmol/l. To clarify if lipid peroxides per se enhances the glycated hemoglobin level, an in vitro study was performed by incubating erythrocyte suspension containing either 5 or 50 mmol/l glucose with or without MDA. Lipid peroxides and glycated hemoglobin levels were determined in the glucose treated cells. RESULTS: Glycated hemoglobin levels were higher in erythrocytes incubated with 50 mmol/l glucose concentrations than in erythrocytes incubated with 5 mmol/l glucose. The increase in glycated hemoglobin levels was blocked significantly when erythrocytes were pretreated with either lipoic acid or taurine. Both the antioxidants used in the present study markedly reduced the MDA levels. The level of glycated hemoglobin in erythrocyte incubated in the presence of MDA was increased significantly when compared to erythrocyte incubated with glucose alone. CONCLUSIONS: Lipid peroxides per se may have a role to play in glycation of hemoglobin and antioxidants (lipoic acid and taurine) can partially inhibit the formation of glycated hemoglobin by lowering the levels of lipid peroxides.
PMID: 16325165 [PubMed - indexed for MEDLINE]
Mol Cell Biochem. 1997 Dec;177(1-2):245-50. Related Articles, Links
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Prevention of lens protein glycation by taurine.
Devamanoharan PS, Ali AH, Varma SD.
Department of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201, USA.
Modifications in lens protein structure and function due to nonenzymic glycosylation and oxidation have been suggested to play a significant role in the pathogenesis of sugar and senile cataracts. The glycation reaction involves an initial Schiff base formation between the protein NH2 groups and the carbonyl group of a reducing sugar. The Schiff base then undergoes several structural modifications, via some oxidative reactions involving oxygen free radicals. Hence certain endogenous tissue components that may inhibit the formation of protein-sugar adduct formation may have a sparing effect against the cataractogenic effects of sugars and reactive oxygen. The eye lens is endowed with significant concentration of taurine, a sulfonated amino acid, and its precursor hypotaurine. It is hypothesized that taurine and hypotaurine may have this purported function of protecting the lens proteins against glycation and subsequent denaturation, in addition to their other functions. The results presented herein suggest that these compounds are indeed capable of protecting glycation competitively by forming Schiff bases with sugar carbonyls, and thereby preventing the glycation of lens proteins per se. In addition, they appear to prevent oxidative damage by scavenging hydroxyl radicals. This was apparent by their preventive effect against the formation of the thiobarbituric acid reactive material generated from deoxy-ribose, when the later was exposed to hydroxyl radicals generated by the action of xanthine oxidase on hypoxanthine in presence of iron.
PMID: 9450669 [PubMed - indexed for MEDLINE]
Posted 14 June 2006 - 03:05 PM
Posted 16 June 2006 - 02:25 PM
Ha ha!Duke is the one that convinced me saccharin was completely safe. If its not, then my blood is on his hands.
Posted 16 June 2006 - 05:39 PM
Posted 05 November 2006 - 07:35 PM
Posted 11 May 2008 - 06:27 PM
Here's an updated regimen:Edited by FunkOdyssey, 11 May 2008 - 06:29 PM.
Posted 11 May 2008 - 06:38 PM
$155 - Total monthly cost
That's not quite a poor man's stack, dude.
Edited by HYP86, 11 May 2008 - 06:40 PM.
Posted 11 May 2008 - 06:52 PM
Posted 11 May 2008 - 08:00 PM
When I said $150 a month was for poor people that was in relation to Shepard's regimen which, at that time, was extremely extensive (probably upwards of $300 a month). I do realize that $150 a month is a significant amount of money, and you're right, few people are willing to make that kind of investment. Then again, most of the people I know in their mid-late 20's spend twice that much every month going out to bars, going out to eat, etc. The current updated regimen above is still probably very close to the $150 / month range.
When I said $150 a month was for poor people that was in relation to Shepard's regimen which, at that time, was extremely extensive (probably upwards of $300 a month). I do realize that $150 a month is a significant amount of money, and you're right, few people are willing to make that kind of investment. Then again, most of the people I know in their mid-late 20's spend twice that much every month going out to bars, going out to eat, etc. The current updated regimen above is still probably very close to the $150 / month range.
Edited by HYP86, 11 May 2008 - 08:10 PM.
Posted 04 June 2008 - 11:50 PM
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