• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

PAYWALLED: SIRT1 Regulation in Ageing and Obesity

aging obesity sirt1

  • Please log in to reply
No replies to this topic

#1 Engadin

  • Guest
  • 198 posts
  • 580
  • Location:Madrid
  • NO

Posted 20 April 2020 - 09:41 PM


.

 

 

 

 

 

P A Y W A L L E D   S O U R C E :   Science Direct

 

 

 

 

 

Highlights

 
  •  Reduced SIRT1 expression or activity in age and obesity associated diseases.
 
  •  Regulation of Sirt1 transcription and SIRT1 RNA and protein stability as determinants of lower SIRT1 expression in ageing and obesity.
 
  •  A decline in NAD levels contributes to low SIRT1 activity in ageing.
 
  •  Modulation of SIRT1 activity and NAD availability as therapeutic strategies to prevent and ameliorate age and obesity associated disorders.
 
 
 
Abstract
 
Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples. The downstream effects of SIRT1 activity have been thoroughly explored, and their research is still in expanse. SIRT1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-II diabetes; 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) DNA damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers.
 
This knowledge intensified the interest in uncovering the mechanisms regulating the expression and activity of SIRT1. This review focuses on the upstream regulatory mechanisms controlling SIRT1, and, how this knowledge could potentially contribute to the development of therapeutic interventions.
 
 
 
 
 
.






Also tagged with one or more of these keywords: aging, obesity, sirt1

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users