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Psychological stress leads to microbleeds in brain and endothelial cell dysfunction

stress microbleeds microbleed

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#1 Delton

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Posted 28 July 2020 - 09:42 PM

Just another reason to keep stress levels low!


See press release here: 
https://irp.nih.gov/...gn=2020 July 23


Full paper (open access) here: 



I wonder if there is any way to reduce this damage...


A quick search doesn't find much for treating microbleeds except keeping blood pressure low with blood pressure medications. 

#2 zorba990

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Posted 28 July 2020 - 10:11 PM

Rutin and or other bioflavonoids work for these kinds of things IME in many cases. Though you may need to water soluble versions for max effect (like Hesperidin Methly Chacone which incidentally shows efficacy against viruses)


Solubility may play major role in the therapeutic efficacy of flavonoids. Low solubility of flavonoid aglycones in water coupled with its short residence time in the intestine as well as its lower absorption does not allow humans to suffer acute toxic effects from the consumption of flavonoids, with the exception of a rare occurrence of allergy. The low solubility of the flavonoids in water often presents a problem for its medicinal applications. Hence, the development of semisynthetic, water-soluble flavonoids, for example, hydroxyethylrutosides and inositol-2-phosphatequercetin, has been implicated for the treatment of hypertension and microbleeding [57]. ( https://www.scienced...00298X?via=ihub )

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#3 Delton

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Posted 29 July 2020 - 12:37 AM

very interesting, thank you!


From the 2nd paper you link to : "semisynthetic flavonoids are used widely in cases of hypertension, water disequilibrium and microbleedings (Radouco-Thomas et al., 1964; Ten Cate et al., 1973; Sempinska et al., 1977). These substances are hydroxyethyl rutosides (Fig. 58). They are given intravenously" 

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