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Fractured emotional response, GAD, & more

brain anxiety feeling pharmacology prescription stress nerves gaba glutamate serotonin

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#31 Furniture

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Posted 16 April 2020 - 08:53 PM

I would like to report 2 small successes here:

 

Agmatine, a mild NMDA antagonist, seems to work just as well as DXM. I was looking for NMDA antagonists that are easily attainable and relatively low in risk and I stumbled upon Agmatine. Right now, I take 2 grams of Agmatine Sulfate in the morning as needed and it seems to work the same day I take it. Even though the relief from Agmatine is not total, there is a small yet clear improvement in my thinking abilities while making eye contact with another person and in my ability to react expressively during a conversation. This is very similar to the results I've gotten from DXM.  This also confirms my belief that glutamate over-activity plays a large part in my "condition". I'd like to try Agmatine & DXM together next, however I worry that DXM could be harmful through chronic use. And, is it safe to take more than one NMDA antagonist concurrently? Another small caveat is that Agmatine appears to reduce my tolerance to strenuous exercise. I normally exercise 3-5 times a week, running laps and stairs and lifting weights. On the days I take Agmatine, I notice that I can't run as many stairs as I usually do and that I tire easily. Since many people take Agmatine specifically to enhance athletic performance, this side effect strikes me as odd and paradoxical. Supposedly, Agmatine inhibits nitric oxide synthase and thereby lowers Nitric Oxide levels, which could explain this.

And secondly,

 

Glucuronolactone, while effecting no change in the symptoms I've outlined in this thread, has had a noticeable improvement on my word recall. I did not mention it here because I thought it would be irrelevant to this topic, but sometimes I struggle to recall the right word that I'm thinking of. Of course, this is normal to an extent. But in my case, those tip-of-the-tongue moments happen to me a little bit more often than I'd like.  I've always attributed this to abusing cannabis during college, but who knows! I just might not be a naturally great writer or possess verbal intelligence. But thankfully, Glucuronolactone seems to ameliorate this a bit!


Edited by Furniture, 16 April 2020 - 09:34 PM.


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#32 Furniture

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Posted 16 April 2020 - 09:34 PM

Thank you to everyone who has responded so far! Your suggestions have been noted. My life is a bit too hectic at the moment to be able to trial all of these supplements and drugs in a safe & methodical fashion. I'm looking to try St. John's Wort, L. Reuteri, or NSI-189 next.  Though, I will probably start with L. Reuteri first out of cautiousness.

 

 

Working list of next possible therapies:

Bumetanide

Sulforphane

Ketamine Infusion Therapy

Lactobacillus reuteri

Selegiline

Cerebrolysin

Fecal Transplant

Homotaurine

Naltrexone

Biotoxin contamination?

Transcranial Magnetic Stimulation

Hormone profile
Buspirone (Buspar)
St. John's Wort
Sarcosine
NSI-189
Semax
Mirtazapine

PQQ
Tianeptine

TUDCA



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Also tagged with one or more of these keywords: brain, anxiety, feeling, pharmacology, prescription, stress, nerves, gaba, glutamate, serotonin

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