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Carotenoids Are Associated With A Younger Epigenetic Age And Reduced All-Cause Mortality Risk

carotenoids epigenetic clocks aging

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#1 Michael Lustgarten

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Posted 14 March 2021 - 10:28 AM



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#2 albedo

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Posted 14 March 2021 - 11:01 AM

Interesting Micheal. Maybe your post should have been tagged as "albumin" vs the proxy you interestingly found (carotenoids).

Due the importance at all ages (and maybe even more older ages) and epigenetic biomarkers I would encourage to look at it independently. I think the most impactful action to take in order to have an adequate level of albumin is adequate nutrition and protein intake, afaik.

A pity GrimAge is not yet commercially available but I guess soon it will be.


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#3 albedo

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Posted 14 March 2021 - 12:52 PM

Interesting Micheal. Maybe your post should have been tagged as "albumin" vs the proxy you interestingly found (carotenoids).

Due the importance at all ages (and maybe even more older ages) and epigenetic biomarkers I would encourage to look at it independently. I think the most impactful action to take in order to have an adequate level of albumin is adequate nutrition and protein intake, afaik.

A pity GrimAge is not yet commercially available but I guess soon it will be.

 

Sorry Michael, I have been overlooking this one:https://michaellustg...lbumin-and-acm/



#4 Michael Lustgarten

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Posted 14 March 2021 - 04:19 PM

Thanks albedo. I usually try to keep the title short, but you're right, I could've included albumin in the title, as that's part of the story. Anecdotally, people have told me that their protein intake is correlated with albumin, but that's not true for my data. Also yes, I've written about albumin before, but it's an underrated biomarker, most don't think about measuring it/overlook it!


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#5 Qowpel

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Posted 16 March 2021 - 10:38 PM

What does this mean for astaxanthin? Also, I am dumb, so how much lower are these epigenetic ages when accounting for apt intake of each of the above caretenoids?


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#6 Michael Lustgarten

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Posted 17 March 2021 - 10:12 AM

Astaxanthin wasn't included in the studies in the video, so I didn't include it. Astaxanthin is indeed a carotenoid with many reported health benefits, and I'll likely cover it in a future video.

For the epigenetic age reduction, they looked at correlations, so the actual reduction is unknown. But, you can see that the magnitude for the reduction was highest for alpha carotene (-0.28), and lowest for lycopene (-0.07). Based on those data, it looks like the epigenetic age reduction for higher blood levels of alpha-carotene was 4x greater than for higher lycopene.


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