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High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

centenarian offspring fgf21 calorie restriction

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#1 Michael Lustgarten

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Posted 30 May 2021 - 11:02 AM


 

Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.scienced....com/science...

 

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm...gov/pmc/arti...

 

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi....ih.gov/18585...

 

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi....ih.gov/32877...

 

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi....ih.gov/31773...

 

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm...gov/pmc/arti...

 

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi....ih.gov/28552...

 

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging: https://pubmed.ncbi....ih.gov/33131...

 

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi....ih.gov/30043...

 

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi....ih.gov/26042...

 

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians' Offspring: https://pubmed.ncbi....ih.gov/15571...

 

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi....ih.gov/20398...


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