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300mg per day NMN increases telomere length significantly


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#1 MikeDC

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Posted 29 November 2021 - 11:32 PM

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#2 QuestforLife

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Posted 06 December 2021 - 12:43 PM

Very interesting, thank you. 





Aging is a natural process with concomitant changes in the gut microbiota and associate

metabolomes. Beta-nicotinamide mononucleotide, an important NAD+ intermediate,
has drawn increasing attention to retard the aging process. We probed the changes
in the fecal microbiota and metabolomes of pre-aging male mice (C57BL/6, age: 16
months) following the oral short-term administration of nicotinamide mononucleotide
(NMN). Considering the telomere length as a molecular gauge for aging, we measured
this in the peripheral blood mononuclear cells (PBMC) of pre-aging mice and human
volunteers (age: 45–60 years old). Notably, the NMN administration did not influence
the body weight and feed intake significantly during the 40 days in pre-aging mice.
Metabolomics suggested 266 upregulated and 58 downregulated serum metabolites.
We identified 34 potential biomarkers linked with the nicotinamide, purine, and
proline metabolism pathways. Nicotinamide mononucleotide significantly reduced the
fecal bacterial diversity (p < 0.05) with the increased abundance of Helicobacter,
Mucispirillum, and Faecalibacterium, and lowered Akkermansia abundance associated
with nicotinamide metabolism. We propose that this reshaped microbiota considerably
lowered the predicated functions of aging with improved immune and cofactors/vitamin
metabolism. Most notably, the telomere length of PBMC was significantly elongated
in the NMN-administered mice and humans.
Taken together, these findings suggest
that oral NMN supplementation in the pre-aging stage might be an effective
strategy to retard aging. We recommend further studies to unravel the underlying
molecular mechanisms and comprehensive clinical trials to validate the effects of NMN
on aging.




Edited by QuestforLife, 06 December 2021 - 12:45 PM.

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