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Lithocholic Acid: A Gut Bacterial Metabolite That Extends Lifespan

lifespan extension

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#1 Michael Lustgarten

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Posted 03 July 2022 - 11:15 AM


https://www.youtube....h?v=dd_TXkHsKVI

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Edited by Mind, 05 July 2022 - 05:35 PM.

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#2 Mind

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Posted 05 July 2022 - 05:33 PM

....in mice.

 

The edit was to fix the youtube link.


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#3 Michael Lustgarten

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Posted 17 July 2022 - 11:16 AM

....in mice.

 

The edit was to fix the youtube link.

 

Ah, more specifically, it extends lifespan in yeast in flies, and is associated with increased lifespan in 2 mouse models of longevity (GHRH KO and CR). 

Whether it extends lifespan in mice is unknown, but I'm submitting a grant next week that will evaluate that!


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#4 Daniel Cooper

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Posted 18 July 2022 - 07:49 PM

Seems like it has some good anti-cancer properties aside from whether it extends life in humans.

 

How would one increase the amount of Lithocholic Acid produced in the gut? Is there a bacteria particularly good at this? Can it be supplemented and is there a source?


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#5 Michael Lustgarten

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Posted 19 July 2022 - 08:42 PM

Great questions. On the video-to do list is figuring out the answers...



#6 Harkijn

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Posted 20 July 2022 - 02:51 PM

See also this older thread:

 

https://www.longecit...ule-identified/


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#7 Michael Lustgarten

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Posted 23 July 2022 - 02:26 PM

That data has been known since 2010, but yet there's so little press on lithocholate since then. In terms of how much is optimal, there's likely a U-shaped association, with too little and too much being bad for health and/or longevity.







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