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Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults

biomarkers

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#1 johnhemming

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  • Location:Birmingham, UK

Posted 30 September 2022 - 06:02 PM


https://www.thelance...3964(22)00474-1

 

Much the same as many others really.

 

 

Findings As few as 8-15 variables predicted longevity at 2-, 5- and 10-years with predictive performance (area under receiver operator characteristic curve) of 0¢76 (95% CIs 0¢69, 0¢83), 0¢76 (0¢72, 0¢81) and 0¢66 (0¢61, 0¢71), respectively. Numbers of small high-density lipoprotein particles, younger age, and fewer pack years of cigarette smoking were the strongest determinants of longevity at 2-, 5- and 10-years, respectively. Physical function was a prominent predictor of longevity at all time horizons. Age and cognitive function contributed to predictions at 5 and 10 years. Age was not among the local 2-year prediction variables (although significant in univariable analysis), thus establishing that age is not a direct cause of 2-year longevity in the context of measured factors in our data that determine longevity.

 


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