I've been thinking about the potential synergy between senolytic compounds and NAD+ precursors as a combined anti-aging strategy, and wanted to get this community's thoughts.The theory is straightforward:- Senolytics (like fisetin or quercetin+dasatinib) clear senescent cells- NAD+ precursors (NMN, NR) support mitochondrial function and cellular repairBut I'm wondering about the practical implementation:1. Timing considerations - Should senolytics be cycled separately from NAD+ support, or can they be combined?2. Mechanistic overlap - Both approaches target cellular aging, but through different mechanisms. Does clearing senescent cells first create a "cleaner slate" for NAD+ to work on remaining healthy cells?3. Dosing protocols - For those who have tried both, what schedule worked best?I've been researching the underlying science and found some interesting perspectives on how these pathways interact at the cellular level: https://www.glunovabio.com/scienceHas anyone here experimented with combining senolytics and NAD+ precursors? Would love to hear about your protocols and any observations on effectiveness.
