GLP-1 drugs finally cracked weight loss, a problem medicine had flailed at for a century. So which "longevity drugs" are anywhere close to doing that for lifespan? Short answer: none. Per candidate:
- Multivitamins and specific vitamins (D, C, E): Randomized controlled tests (RCTs) have shown no benefit
- Fish oil: RCTs haven't worked out, and dementia studies showed a trend toward increasing (!?) dementia
- Resveratrol and NMN: Sinclair’s attempts to do CR in a pill. Both failed.
- Rapamycin: RCTs failed to meet their target endpoints
- Metformin: superb for diabetics, not helpful for lifespan
- Aspirin: bleeding risk got it pulled from healthy-elderly advice.
- GLP-1: the early “longevity” wins look like mostly weight loss.
My bet: the first real longevity drug is still unwritten. When a pill adds years to healthy people the way Ozempic drops pounds, that’s the actual Ozempic Challenge. We’re not there yet.
Full writeup with the studies: https://www.unaging....ongevity-drugs/
Edited by Cloomis, Today, 08:50 AM.
