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#451 opendoor

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Posted 13 September 2009 - 01:12 PM

Is GSK running their own resveratrol trial in colon Ca? They haven't had enough time for that, have they? Are you thinking of this UCI/UCLA trial?


Ah , niner, ever the stand-up!...

I don't know any details. But 60 Minutes reported that early cancer trial results were due this month, and I read a Sirtris press realese from 2008 that SRT501 was being used to treat colon cancer. You didn't know this?

I guess we'll know more next week at the Harvard longeveity pow-wow.

Edited by opendoor, 13 September 2009 - 01:32 PM.


#452 missminni

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Posted 13 September 2009 - 02:42 PM

Avandia is having some serious problems by causing heart attacks as a side effect. They need a replacement. That explains why the pursuit of res for diabetes instead of cancer.


But GSK is about to announce early colon cancer trial results soon unless they have decided to wait. I think it's going to be good news. If the results are very positive, I wonder what they would do with SRT501.

Is GSK running their own resveratrol trial in colon Ca? They haven't had enough time for that, have they? Are you thinking of this UCI/UCLA trial?

Primary Outcome Measures:
Test the hypothesis that resveratrol modulates Wnt signaling in vivo in colon cancer and normal colonic mucosa [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 12
Study Start Date: July 2005
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)

Intervention Details:
Drug: Resveratrol
The first two patients receiving resveratrol pills will be treated at a dose of 20mg/day, the third and fourth patients at a dose of 80mg/day and the fifth and sixth patients at a dose of 160mg/day

Pretty disappointing regimen. I guess it was cutting edge in '05...

I can't believe the highest dose is 160 mg. It's ridiculous. If they have any success I will be shocked.

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#453 maxwatt

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Posted 13 September 2009 - 06:39 PM

Avandia is having some serious problems by causing heart attacks as a side effect. They need a replacement. That explains why the pursuit of res for diabetes instead of cancer.


But GSK is about to announce early colon cancer trial results soon unless they have decided to wait. I think it's going to be good news. If the results are very positive, I wonder what they would do with SRT501.

Is GSK running their own resveratrol trial in colon Ca? They haven't had enough time for that, have they? Are you thinking of this UCI/UCLA trial?

Primary Outcome Measures:
Test the hypothesis that resveratrol modulates Wnt signaling in vivo in colon cancer and normal colonic mucosa [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 12
Study Start Date: July 2005
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)

Intervention Details:
Drug: Resveratrol
The first two patients receiving resveratrol pills will be treated at a dose of 20mg/day, the third and fourth patients at a dose of 80mg/day and the fifth and sixth patients at a dose of 160mg/day

Pretty disappointing regimen. I guess it was cutting edge in '05...

I can't believe the highest dose is 160 mg. It's ridiculous. If they have any success I will be shocked.


When they started the study, pharmaceutical grade synthetic resveratrol cost $10,000 a kilo.

#454 niner

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Posted 13 September 2009 - 09:15 PM

When they started the study, pharmaceutical grade synthetic resveratrol cost $10,000 a kilo.

That's only ten bucks a gram... That's cheaper than Viagra. Do you know about this alleged "other" colon cancer study that "GSK" is supposedly running?

#455 maxwatt

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Posted 14 September 2009 - 01:58 AM

When they started the study, pharmaceutical grade synthetic resveratrol cost $10,000 a kilo.

That's only ten bucks a gram... That's cheaper than Viagra. Do you know about this alleged "other" colon cancer study that "GSK" is supposedly running?


Can't find the anything on the list of FDA approved studies, and I doubt they are free-lancing,

#456 opendoor

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Posted 14 September 2009 - 02:33 AM

Found one, but I recall another as well:

"Sirtris' most publicized drug compound, SRT501, a potent blend of micronized resveratrol, is being put on the back burner for treatment of Diabetes in hopes Sirtris' own new replacement SRT2104, a NCE (New Chemical Entity) will provide an even more powerful pharmaceutical replacement. SRT501 will continue to be used in trials for the treatment of colon cancer and MELAS syndrome."

http://stanford.well...reported/465397


If 60 Minutes is correct, some announcement may be given at around the time of the Longevity conference on Sep 23rd where the big names are presenting.



This is the clip that mentions early Sirtis cancer results were expected in September (last minute)
http://www.cbsnews.c...ch/?id=5037314n

So if SRT501 looked promising, would GSK say "good news, but wait for SRT 2104"?

Edited by opendoor, 14 September 2009 - 02:33 AM.


#457 opendoor

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Posted 15 September 2009 - 02:42 AM

So what say niner and maxwatt on SRT501 being used to treat colon cancer and the 60 Minutes report that mentioned that Sirtris would have early cancer trial results this month? Is it odd that it isn't listed on an FDA list?

#458 niner

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Posted 15 September 2009 - 02:55 AM

So what say niner and maxwatt on SRT501 being used to treat colon cancer and the 60 Minutes report that mentioned that Sirtris would have early cancer trial results this month? Is it odd that it isn't listed on an FDA list?

Seems a bit odd, but I don't know the law on that. I certainly hope that there has been a high dose trial, since the UCI study used ridiculously low doses. I just wish we had more to go on than 60 Minutes.

#459 opendoor

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Posted 15 September 2009 - 04:39 AM

Seems a bit odd, but I don't know the law on that. I certainly hope that there has been a high dose trial, since the UCI study used ridiculously low doses. I just wish we had more to go on than 60 Minutes.


It is almost certainly SRT501 at 2.5g or so. I forget how much resveratrol that would be, but well over 1g, right?

But there is the Sep 23rd Longevity conference, so it seems likely, as one person told me, that it is meant to coincide with the latest research. One aspect 60 Minutes didn't mention was that there is SRT501 and SRT2041. The former might be used for the cancer trials, and the latter is what Sinclair thinks will be out by 2014 "to be conservative."

Edited by opendoor, 15 September 2009 - 04:41 AM.


#460 maxwatt

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Posted 15 September 2009 - 01:03 PM

see HERE.
N.B.: 60 Minutes is not a reliable source whenever the announcer's lips are moving.

Edited by maxwatt, 15 September 2009 - 01:05 PM.
fix spelling and gramer


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#461 opendoor

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Posted 15 September 2009 - 11:40 PM

see HERE.
N.B.: 60 Minutes is not a reliable source whenever the announcer's lips are moving.


A bit harsh? Thanks for linking the above, though. I thought overall the 60 Minutes segment was quite good considering how journalists have made errors in the past, as with the BusinessWeek article. I thought there were a couple of places where statements didn't quite add up with respect to what the SRT pills could potentially do, but why would 60 Minutes get the "early cancer results in September" part wrong? Obiously Sirtris told them that. It doesn't mean they would necessarily announce those results then, though. Still, with the whole gang meeting at the Longevity conference on Sep 23rd, I bet we get news regarding the study.




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