284 replies to this topic

[Animal]

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$hole behavior

What dose were you taking?

5mg, I should have taken more though, breaking up with her earlier would have been in my best interest. Hindsight is 20/20.

LoL, I thought your relationship was going well? I'm on 10mg/day and my love life is a mess right now, but I can't blame the deprenyl, I've always been an asshole.

[FunkOdyssey]

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$hole behavior

What dose were you taking?

5mg, I should have taken more though, breaking up with her earlier would have been in my best interest. Hindsight is 20/20.

LoL, I thought your relationship was going well? I'm on 10mg/day and my love life is a mess right now, but I can't blame the deprenyl, I've always been an asshole.

No, haha. Big Whores Come In Little Packages (a five year ride to nowhere)

[tintinet]

My condolences and empathy, FunkOdyssey. Could be worse. Try a 20 year ride to nowhere with kids! Marriage can be bad for your mental, physical, and financial health.

WRT the NOW ECGC, I will try it, but it may a be a while. I'm not to excited about spending more money on supplements right now.

[ajnast4r]

green tea extract: exacerbates my asthma every time
kava: EXCELLENT for occasional bouts of insomnia, but if used for more than a few days leads to pretty nasty depression
quercetin: insomnia
vitamin D 4000iu (above 40-45ng/mL): increase in trigger points/muscle tension

[Lufega]

Resveratrol in the setting of Iron deficiency anemia. I started my girlfriend on it just to finish a bottle I had. Well, she has a long standing case of iron deficiency anemia that only shows up in her blood work. That is, she has no physical signs of it. After being on res. for a couple of weeks, she started developing bruises everywhere and some upper GI bleeding. She started to ask me why she burped and it tasted like liver (bloody burps? There was also a few instances of tarry poop) I went crazy trying to figure out what was causing this sudden exacerbation and I concluded that it was the resveratrol. But, I don't think it was through chelating iron directly but by reducing the concentration of copper. In copper deficiency, patients can sometimes suffer from anemia because of a lack of iron. This is because the proteins needed to absorb iron are copper dependent.

[Destiny's Equation]

Ephedra- Took it when I was a foolish teenager with body image issues. Anxiety, tremors...what a nightmare!

CDP Choline- Gives me nasty headaches. Small price to pay though, it works wonders for my encephalopathy symptoms.

6. Cayenne - Can cause neuropathy (used to elicit neuropathy in standard research models)

Too much of ANY substance can be neurotoxic, even water. The dose makes the poison.

[rwac]

CDP Choline- Gives me nasty headaches. Small price to pay though, it works wonders for my encephalopathy symptoms.

Is it possible that the extra choline is giving you the headaches, but you're being helped by the cytidine (it's a nucleotide) ?

You might want to try an RNA extract. I find the LEF RNA is a good deal.

[Dmitri]

High dose of Vitamin E, and high Gamma E - made me feel terrible.
Low dose of full spectrum E works.

What would you consider high dose Vitamin E? I'm planning to buy a full spectrum Vitamin E supplement which contains the following: 400 IU of Alpha Tocopherol, 391 mg of the remaining tocopherols and 133 mg of tocotrienols. Would you consider this a high dose?

[rwac]

What would you consider high dose Vitamin E? I'm planning to buy a full spectrum Vitamin E supplement which contains the following: 400 IU of Alpha Tocopherol, 391 mg of the remaining tocopherols and 133 mg of tocotrienols. Would you consider this a high dose?

I was referring to a alpha-tocopherol only supplement. Make sure that Gamma > Alpha, maybe even 2x or 4x.

[woly]

DHEA - significantly reduced my libido, probably by increasing estrones.

High dose of Vitamin E, and high Gamma E - made me feel terrible.
Low dose of full spectrum E works.

Krill oil - Caused Nausea. Tried two separate batches, same effect. I cannot tolerate krill oil.

high dose vitamin E and Gamma E does the same to me. I also feel sick on it.

I found taking a single Jarrows FamilE capsule would usually result in GI upsets within the next 4-24 hours. I take Gamma E now and still get cramps sometimes.

[panhedonic]

During my 2nd week on it Deprenyl (not a supplement though) started to cause EXTREME night-time fears which were then followed by hallucinations of presense and one instance of auditory hallucination (radio noise).

Nasty!

How much Deprenyl were you taking to cause this unfortunate side effect?

Sorry to bump this, but what brand? and what's "Presense"? How many times did this happen?
What else were you on?

I'm considering starting on Deprenyl, but I had night-terror in the past due to bad DMT flash-backs and I wouldn't want to bring those back in.

Edited by brainjuice, 29 March 2012 - 06:05 PM.

[Hope47]

Ashawgandha makes me depressed and dizzy.

[hippocampus]

Lecithin, milk thistle - make me depressed - they didn't make me depressed for a few months, but now they make me depressed every time I take them.
more than 30 mg zinc a day - headache
5-htp - sleep paralysis (taken before sleep) or sleepiness (taken in the morning)
methylene blue - more than 200 mcg destroys my short-term memory and I my breathing becomes strange (like anxiety although I'm not anxious).

[Blankspace]

Some of the following supplements were effective, but had side effects that outweighed their benefits.

5-htp(50mg): Caused aggressive temporary acne, symptoms stopped when supplementation stopped.
SAM-e(400mg): Caused a fever and a terrible headache, it made me sleep for 16+ hours. Awful experience. -No positive effects.
Uridine/Cytidine(25mg): http://www.longecity...post__p__506259
Choline Bitartate(250mg): Exacerbated anxiety making it difficult to carry on conversations. Caused panic attacks in social situations.

[kingjoefromflorida]

I gotta chime in on this one.I think I just figured out what was causing the tingling feet I had a couple years ago.At the time I was supplementing with cayenne pills,and back then I had a bad habit of taking large amounts.My thinking was it would improve blood flow to key area if you get my drift :)Anyways during that same month I developed this odd sweating of my feet and it felt like when I walked across the floor(really noticable on wood floors)my feet felt tingly and almost like shocks going through them.I also noticed this when I was driving.It never occured to me that I caused it myself.I did end up going to the doctors for something else.In my mind I was thinking oh no I have diabetes or something as in neuropathy in feet....the doctor thought i was nuts and said No way was I diabetic...So cayenne pills can do that?I was also taking around 7 grams of vitamin c a day at that time.I have never experienced it since either and have never taken those cayenne pills either...

[YanaRay]

Anything containing more than 20mg iron makes me seriously nauseous, funnily - even more in the morning. I cannot take it on an empty stomach as I'm on the verge of throwing up for an hour or so. Similar effect - vitamin B12 standard dose tablets. This is very strange as I've got a very healthy stomach and not at all sensitive to common drug irritants such as ibuprofen/naproxen or diclofenac. I can eat/drink whatever I please and my digestive system remains unaffected (the only exception being excess coffee or tea).

[JChief]

Tyrosine - anxiety attack

NAC - either caused or at least aggravated a peptic ulcer (strips protective mucous from stomach lining)

Inositol - indigestable or unabsorbable, produces terrible gas

Phosphatidylserine - terrible fatigue and brain fog

Relora - terrible fatigue and brain fog

Anything That Reduces Cortisol Levels - terrible fatigue and brain fog

Curcumin - killed libido dead at higher doses (mTOR inhibition?)

Taurine - high dose (4 grams) long-term (over a year) caused anxiety

DHEA - 50mg daily elevated estrone levels and reduced testosterone by 40%

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$$hole behavior

Olive Leaf Extract - consistently terrible reaction to this, severe fatigue, brain fog, anxiety, not sure if its a side effect, allergy, or herx reaction

Tryptophan - makes me feel like I'm going to pass out, dizzy, low blood pressure.


This is just off the top of my head, if I went back through my journal I know I could find alot more.'

edit: forgot serrapeptase irritated my lungs too, made me wheezy/asthmatic.

I've tried many of these myself over time and most I have not had nearly the reactions as you. Everyone is unique though. Most of the above did not produce any effect whatsoever. Olive Leaf for instance was just taken to improve immune function. Inositol powder from AOR tastes very sweet and was easy to take with water, no problems.

[Turnbuckle]

I've taken supplements since 1970 and Resveratrol was definitely the worst. It almost crippled me with knee and hip pain until I realized where it was coming from.

[nowayout]

I've taken supplements since 1970 and Resveratrol was definitely the worst. It almost crippled me with knee and hip pain until I realized where it was coming from.

I think a short course of Resveratrol triggered Ankylosing Spondylitis in me 3 years ago. Now I'll always have this condition. It is not a supplement to be taken lightly.

[ironfistx]

Magnesium Malate - heart palpitations (even at a single 200mg dose)

Magnesium Glycinate - heart palpitations (even at a single 200mg dose)

Bromelain - heart palpitations (at 500mg @ 2,000GDU or above)

Curcumin - loss of libido, diarrhea (even at 1/3 pill dose)

[anagram]

histidine
-it made me feel like I was dying on some weird level.
and it turns out I was right to some extent
http://www.ncbi.nlm..../pubmed/9007529

Edited by anagram, 16 January 2013 - 12:12 AM.

[hbar]

I've recently stopped taking ALL supplements, because of some health issues. First up was some intestinal discomfort I was having, which I thought was due to taking aspirin. Stopped that, though there's still some discomfort.

Second, tried taking a higher dose of fish oil (3g) - got really tired and started getting headaches.

Lastly, I've had a major loss of libido, as well as what I feel has been a loss of size "down there". About 5 months ago I had added a couple supplements - zinc glycinate (30mg every other day) and iodine (KI, 225mcg per day). I had also changed from mag glycinate to mag taurinate, and switched multis (from Multi Basics to Nature's Way Alive - one every other day). Initially all felt fine, and actually I'm positive that the zinc increased my libido significantly. Yet about 2 months ago, I started having erectile issues which given my age has been super frustrating.

I thought maybe it was due to too much zinc or not enough copper (since the zinc supplement doesn't have copper in it), but I've stopped taking everything for almost a month now and the problem's still there.

I'm super frustrated by this, and quite frankly am considering never taking supplements again. I'm very conservative in my approach to vitamins/minerals, and don't megadose anything (my regimen consisted of 1 multi, LEF's Super K, and 30mg zinc every other day, and 1g fish oil, 1000 IU Vit D, 225mcg KI, 81mg aspirin, and 200mg mag taurinate every day). If that level of supplementation is enough to cause noticeable negative health effects, then what's the point? I'm going to continue not taking anything and see if the libido issues subside, but this may be my last foray into anything other than a basic multi :(

[ironfistx]

Second, tried taking a higher dose of fish oil (3g) - got really tired and started getting headaches.

I get tired when I take 1+g of fish oil (I made a thread about it but it didn't get any replies). I also notice that it gives me a mild headache when I first start taking it after a period of not having taken any, but this goes away after a day or two.

Lastly, I've had a major loss of libido, as well as what I feel has been a loss of size "down there". About 5 months ago I had added a couple supplements - zinc glycinate (30mg every other day) and iodine (KI, 225mcg per day). I had also changed from mag glycinate to mag taurinate, and switched multis (from Multi Basics to Nature's Way Alive - one every other day). Initially all felt fine, and actually I'm positive that the zinc increased my libido significantly. Yet about 2 months ago, I started having erectile issues which given my age has been super frustrating.

I thought maybe it was due to too much zinc or not enough copper (since the zinc supplement doesn't have copper in it), but I've stopped taking everything for almost a month now and the problem's still there.

It's weird that you mention that. Occasionally I will take 2mg of copper, and the next day I feel like my erection is a little smaller/weaker than usual. This goes away with a day or two of stopping the copper.

I'm super frustrated by this, and quite frankly am considering never taking supplements again. I'm very conservative in my approach to vitamins/minerals, and don't megadose anything (my regimen consisted of 1 multi, LEF's Super K, and 30mg zinc every other day, and 1g fish oil, 1000 IU Vit D, 225mcg KI, 81mg aspirin, and 200mg mag taurinate every day). If that level of supplementation is enough to cause noticeable negative health effects, then what's the point? I'm going to continue not taking anything and see if the libido issues subside, but this may be my last foray into anything other than a basic multi :(

Honestly dude, maybe you don't need any supplements. Have you tried getting your vitamins from fruits and veggies instead?

Or maybe you're sensitive to the fillers or something. I remember using a generic multivitamin once and it gave me heartburn every single time. It was a low dose multi, too, so it's not like I was taking a huge dose of something.

Edited by ironfistx, 16 January 2013 - 04:20 PM.

[npcomplete]

I have been taking supplements for decades, and the only supplement that ever gave me a strong negative reaction was alpha lipoic acid. I would take it with food, without food, pre-meal, post-meal, whatever, it didn't matter. I would get extreme heartburn. This was a high quality racemic version (I never buy cheap stuff), that I took prior to the r enantiomer becoming common in the marketplace. I have heard that some people have problems with the r enantiomer too.

So this is good news/bad news for me. The bad news is that I simply can't take it. The good news is the same as the bad news: I simply can't take it.

Alpha Lipoic Acid seems to be out of favor now in longevity circles, so skipping it is apparently a good thing, and my body is forcing me to skip it and not waste my money... or should I say, force me to waste money on other things!

[Guardian4981]

I've recently stopped taking ALL supplements, because of some health issues. First up was some intestinal discomfort I was having, which I thought was due to taking aspirin. Stopped that, though there's still some discomfort.

Second, tried taking a higher dose of fish oil (3g) - got really tired and started getting headaches.

Lastly, I've had a major loss of libido, as well as what I feel has been a loss of size "down there". About 5 months ago I had added a couple supplements - zinc glycinate (30mg every other day) and iodine (KI, 225mcg per day). I had also changed from mag glycinate to mag taurinate, and switched multis (from Multi Basics to Nature's Way Alive - one every other day). Initially all felt fine, and actually I'm positive that the zinc increased my libido significantly. Yet about 2 months ago, I started having erectile issues which given my age has been super frustrating.

I thought maybe it was due to too much zinc or not enough copper (since the zinc supplement doesn't have copper in it), but I've stopped taking everything for almost a month now and the problem's still there.

I'm super frustrated by this, and quite frankly am considering never taking supplements again. I'm very conservative in my approach to vitamins/minerals, and don't megadose anything (my regimen consisted of 1 multi, LEF's Super K, and 30mg zinc every other day, and 1g fish oil, 1000 IU Vit D, 225mcg KI, 81mg aspirin, and 200mg mag taurinate every day). If that level of supplementation is enough to cause noticeable negative health effects, then what's the point? I'm going to continue not taking anything and see if the libido issues subside, but this may be my last foray into anything other than a basic multi :(

Major loss of libido and losing size "down there." I would talk to a Doctor but its possible you may have some kind of thyroid issue, low thyroid function lowers libido. It could potentially influence size in that it plays a role with blood volume.

[Guardian4981]

Vitamin D3- Causes my blood sugar to drop sharply
Fish Oil- Causes my allergies to get worse and nasals to congest
Choline- Gives me bad headache that lasts all day unless I take something, and even if I take something it will return after a couple hours
St Johns Wort- After a month or so made me really depressed and also caused my right eye lid to twitch literally all day every day
Fo Ti- Perhaps my worst experience with a supplement gave me really bad anxiety
Vitamin B6- Gave me bad anxiety, numbness in extremeties
Vitamin B12- Seems to give me lethargy
Tyrosine- Causes an uplift in energy for a couple hours and then real bad depression afterward
Rhodiola- Causes me to be very irritable
Guggul- Not "awful" per say but seemed to cause tenderness in my nipple area, must influence estrogen I am thinking
Lithium- Perhaps my most hated supplement, even a dose of 5mg for a month gave me issues with balance, motivation, energy, and blood flow. Even after stopping it the issues persisted. I believe Lithium may have partially fried my thyroid. I have gotten relief with thyroid glandular, ashwaghanda, selenium, and kelp but hope I will not have to stay on these indefinately.
Uridine- Helped my mood alot but killed libido and causes tingling of the skin all over body along with numbness in feet. I may still try stacking this with things in the future.
Cissus- Similar experience to uridine, not as harsh but also not as good of benefits
Turmeric- Headache and depression along with low libido

Supplements that have worked the best for me
TMG
Wheatgrass
Thyroid glandular
Astaxanathin

[anagram]

dosn't TMG break down to a nitroxide I cannot think of it, but it is linked fairly strongly to heart problems and arterial issues?
I personally stopped taking TMG because it gave me a congested feeling in my chest, little did I know it was linked to arteriosclerosis, not going to touch that stuff again.

[Guardian4981]

From what I read TMG raises cholesterol but the study used a dosage I believe over 3 grams daily. The recomended dose is 500mg-1 gram, will this dose still cause issues? Not sure I recal the concensus was this dose likely was safe.

I balance this with high garlic use and low dose olive leaf extract which both help to lower cholesterol.

I also hypothesize that higher testosterone production lowers cholesterol since it uses cholesterol to produce testosterone, I am pretty much always using something that mildy boosts testosterone, usually stinging nettle, ashwaghanda, longjack, and soon to try forskollin.

[niner]

histidine
-it made me feel like I was dying on some weird level.
and it turns out I was right to some extent
http://www.ncbi.nlm..../pubmed/9007529

Why? Are you drinking large amounts of hydrogen peroxide?

[niner]

I've recently stopped taking ALL supplements, because of some health issues. First up was some intestinal discomfort I was having, which I thought was due to taking aspirin. Stopped that, though there's still some discomfort.

Second, tried taking a higher dose of fish oil (3g) - got really tired and started getting headaches.

Lastly, I've had a major loss of libido, as well as what I feel has been a loss of size "down there". About 5 months ago I had added a couple supplements - zinc glycinate (30mg every other day) and iodine (KI, 225mcg per day). I had also changed from mag glycinate to mag taurinate, and switched multis (from Multi Basics to Nature's Way Alive - one every other day). Initially all felt fine, and actually I'm positive that the zinc increased my libido significantly. Yet about 2 months ago, I started having erectile issues which given my age has been super frustrating.

I thought maybe it was due to too much zinc or not enough copper (since the zinc supplement doesn't have copper in it), but I've stopped taking everything for almost a month now and the problem's still there.

I'm super frustrated by this, and quite frankly am considering never taking supplements again. I'm very conservative in my approach to vitamins/minerals, and don't megadose anything (my regimen consisted of 1 multi, LEF's Super K, and 30mg zinc every other day, and 1g fish oil, 1000 IU Vit D, 225mcg KI, 81mg aspirin, and 200mg mag taurinate every day). If that level of supplementation is enough to cause noticeable negative health effects, then what's the point? I'm going to continue not taking anything and see if the libido issues subside, but this may be my last foray into anything other than a basic multi :(

Sorry you're feeling poorly hbar. The only thing that really seems causative here (assuming it stopped when you backed off the dose) is the headache from high dose fish oil. For the rest of it, if you stop the supplement but the problem remains, the cause is probably something else. You have a very sane regimen; I don't see anything that should cause a problem, although you never know. Is your overall zinc/copper ratio around 10:1? (the multi probably has both)