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Persistant depression


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#121 Yearningforyears

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Posted 13 November 2010 - 02:09 AM

Well I do seem to be better at remembering numbers and my executive function is also better at work. (taking on harder tasks is something that is more appealing)
I don´t do any self monitoring when having conversations now either. Verbal fluency is better too.
This is likely because of decreased anxiety and improved mood rather than some high tech brain enhancement.
I´ve always had these kind of voices (but they are only extremely negative thoughts and crappy world view), but these have disappeared as well.
Not that it has turned into some "we are the world" or something. It just feels pretty sweet
You know what´s funny? The last three days I have been waking up in the middle of the night feeling wide awake (bad sign I know), but falling asleep again after that isn´t very hard. Still getting my 7 hours minimum every night, so it looks pretty promising.

This whole thing has gotten me thinking... What on earth is the aniracetam doing? It works super fast (just as fast as the antipsychotic did when I was severly manic) and then it stays in the zone for a long time after the acute intoxication is over (yep... it has a high feeling to it for the first ten minutes or something).
Maybe chronically low dopamine could have something to do with it. That would explain some of the social anxiety perhaps?
L-tyrosine didn´t do a thing though, besides making me angry O_o
Oh well. Let´s hope this ride lasts. Everything looks stable and good so far (it did give some sort of brain fog the first day, but after that it was all good stuff).

Edited by Nicholas, 13 November 2010 - 02:11 AM.


#122 nito

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Posted 13 November 2010 - 04:09 AM

Well I do seem to be better at remembering numbers and my executive function is also better at work. (taking on harder tasks is something that is more appealing)
I don´t do any self monitoring when having conversations now either. Verbal fluency is better too.
This is likely because of decreased anxiety and improved mood rather than some high tech brain enhancement.
I´ve always had these kind of voices (but they are only extremely negative thoughts and crappy world view), but these have disappeared as well.
Not that it has turned into some "we are the world" or something. It just feels pretty sweet
You know what´s funny? The last three days I have been waking up in the middle of the night feeling wide awake (bad sign I know), but falling asleep again after that isn´t very hard. Still getting my 7 hours minimum every night, so it looks pretty promising.

This whole thing has gotten me thinking... What on earth is the aniracetam doing? It works super fast (just as fast as the antipsychotic did when I was severly manic) and then it stays in the zone for a long time after the acute intoxication is over (yep... it has a high feeling to it for the first ten minutes or something).
Maybe chronically low dopamine could have something to do with it. That would explain some of the social anxiety perhaps?
L-tyrosine didn´t do a thing though, besides making me angry O_o
Oh well. Let´s hope this ride lasts. Everything looks stable and good so far (it did give some sort of brain fog the first day, but after that it was all good stuff).




That's cool!
How much of a tea spoon a day do you take and of often?

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#123 Yearningforyears

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Posted 13 November 2010 - 10:18 AM

Do be honest I really don´t know how much I am taking but it´s definitely not more than one gram daily. I´ll update when my 30 gram jar is out of powder ;)
(spread out between several doses, with a larger one in the morning)
I never should have combined this stuff with piracetam. This alone is perfect.

#124 tham

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Posted 28 November 2010 - 06:54 PM

The old tetracyclic, mirtazapine.


http://www.psycard.c...11141739640.pdf

http://www.ncbi.nlm....t_uids=19193341

http://www.ncbi.nlm....t_uids=20531012


http://www.nomorepan...ead.php?t=38920

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#125 Thorsten3

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Posted 13 January 2011 - 12:25 PM

The old tetracyclic, mirtazapine.


http://www.psycard.c...11141739640.pdf

http://www.ncbi.nlm....t_uids=19193341

http://www.ncbi.nlm....t_uids=20531012


http://www.nomorepan...ead.php?t=38920


Thanks I am giving mirtzapine serious consideration right now.

I am back on agomelatine right now after an unsuccessful re-trial with tianeptine. SSRI's are not an option for me even at low dose.

Mirtzapine confuses the hell out of me.. I really don't understand how it works. I know it targets individual receptors as an inverse agonist .. Also it acts on a2 receptors bringing about agonism of 5HT-1A (which is a key player in depression)... How an inverse agonist differs from being an antagonist I don't know.. Being an inverse agonist at 5HT2-C would that provide downstream dopamine release as this the case with agomelatine? The sedation sounds like a bitch though... Still this could be an experiment for me at least. Who knows this could be a really cool anti-depressant for me.

To be fair I am thinking about sticking with agomelatine. Whatever Remeron does, agomelatine can do as well. Mood, anxiety (to a certain extent), appetite (not overly but do I need this side of it? no), sleep, libido (i get crazy libido stimulation from this even at 25mg)...I'll probably still buy some remerson just to try it out and will keep you guys posted.

Edited by Thorsten, 13 January 2011 - 12:28 PM.





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