8 replies to this topic

[LBGSHI]

After reading threads on various forums touting the benefits of centrophenoxine, I ordered a bottle and tried it out. It certainly does seem to be quite effective when combined with aniracetam (or, perhaps aniracetam is quite effective when combined with centrophenoxine). However, I have a couple of questions:

1. It was advised to use centrophenoxine to replace the existing choline source taken with a racetam, so as to avoid too large an increase of acetylcholine in the system. I followed this advice (replacing alpha-GPC), and it seems to hold true at first, but later in the day, whether after a second dose of both aniracetam and centrophenoxine or with no second dose at all, I seem to be mentally fatigued, as if I've burned myself out. This is the same feeling I once had when I took either piracetam or aniracetam without a choline source. I've seen mention of choline bitartrate, choline citrate, CDP choline, and alpha-GPC all donating choline to be metabolized into acetylcholine, but centrophenoxine is only mentioned as facilitating the release of acetylcholine. Does this mean I should still be supplementing with a choline source? If not, where exactly is the choline coming from?

2. I realize this is a common side-effect - when taken on an empty stomach, centrophenoxine gives me nausea which borders on being painful. If taken with food, I don't notice any such effect. This is quite well-known, but what I can't find anywhere is WHY it causes stomach distress. Any ideas?

Edited by lbgshi, 03 February 2012 - 12:56 AM.

[LBGSHI]

Heh, this thread is now the first Google result for the search "centrophenoxine replace" (without quotes), as well as "centrophenoxine replace alpha-gpc" (without quotes). I guess I picked the right forum.

Edited by lbgshi, 03 February 2012 - 03:08 PM.

[Baten]

Personally I can't help you. No stomache distress, no mental fatigue when taking centrophenoxine doses at 1g on an empty stomache.

Edited by Baten, 03 February 2012 - 03:19 PM.

[LBGSHI]

Cool, good to hear it doesn't effect everyone in that way. Either your stomach lining is tougher than mine, your nerves aren't as sensitive as mine to whatever's occurring, or your stomach acid+enzymes/etc are either neutralizing the culprit or, alternately, not creating the culprit while mine are (somehow).

Hmm...according to this thread, concerning centrophenoxine:

http://www.longecity...oxine-research/

"By adding a methyl group (CH3) to DMAE, choline (also called trimethy-laminoethanol) is formed. The choline thus formed may then be used to make other valuable biochemicals, such as the major neurotransmitter acetylcholine, or the essential membrane constituents phosphatidylcholine and sphingomyelin."

This would mean that centrophenoxine actually CONTAINS choline. Can anyone confirm this?

[niner]

This would mean that centrophenoxine actually CONTAINS choline. Can anyone confirm this?

No, it doesn't. Centrophenoxine and choline are two different compounds. By the appropriate chemical reactions, you might be able to make one from the other, but that's different than being a mixture of two compounds.

[angela86]

This would mean that centrophenoxine actually CONTAINS choline. Can anyone confirm this?

No, it doesn't. Centrophenoxine and choline are two different compounds. By the appropriate chemical reactions, you might be able to make one from the other, but that's different than being a mixture of two compounds.

From what I understand you don't need a choline source since it's already a form of DMAE, and DMAE is converted to choline inside of your liver. You'll already get an adequate amount, trust me I have been taking 250 mg every day for awhile now with 4.5 mg of Hydergine - and it's been perfect for me. I've heard that you're supposed to take a break with maybe 1-2 days a week since it's a minor stimulant, and that's what I've been doing.

[LBGSHI]

No, it doesn't. Centrophenoxine and choline are two different compounds. By the appropriate chemical reactions, you might be able to make one from the other, but that's different than being a mixture of two compounds.

Ah, I was thinking centrophenoxine contained CH3. My mistake. Thanks.

From what I understand you don't need a choline source since it's already a form of DMAE, and DMAE is converted to choline inside of your liver. You'll already get an adequate amount, trust me I have been taking 250 mg every day for awhile now with 4.5 mg of Hydergine - and it's been perfect for me. I've heard that you're supposed to take a break with maybe 1-2 days a week since it's a minor stimulant, and that's what I've been doing.

Good to hear. Hmm...I'll consider taking breaks if necessary. Thanks.


So...no one has a clue as to exactly why centrophenoxine causes stomach distress in some people?

[LBGSHI]

As a follow-up, I've noticed that all my bottles of centrophenoxine (two different orders of two bottles each) have an issue with the 'cotton' (I believe it's actually rayon, correct?) being stuck to all the capsules. Basically, each capsule is coated in a tiny layer of the stuff. Could this be what causes the stomach ache immediately after consumption? Would eating that material be a problem?

I'm tempted to just eat a very small piece of it, without any centrophenoxine, to see if I still get the stomach ache...

Does anyone else's centrophenoxine have this issue? I got mine from Cognitive Nutrition, which is where I also get my Piracetam and Aniracetam, which haven't had the same problem any of the times I got them.

[Baten]

If you're worried about the cotton you could try emptying the the capsules and put the powder on your tongue and drink with some water,
or just put it in a glass of water. Centrophenoxine tastes nasty, though. I take 1g powder every other morning, so it's definitely doable (I close off my nose, lol).