Supplement that has had largest effect on skin
#121
Posted 30 July 2013 - 03:58 AM
#122
Posted 30 July 2013 - 06:59 PM
For those who say that c60 olive oil works wonders for the skin, I am wondering if you mean from internal application or external? Also, how long would the 30 ml bottle last and how exactly is the applicator used? Thanks.
They're eating it. You can make it yourself and play. Maybe it's safe. Buy it from SES, crush it with a pestle, measure it, dump the black mess into a bottle of oil, shake the oil bottle for a few weeks, a month. The oil turns reddish in color, and particles get smaller till they appear to disappear. Point ur cat toy fun laser into the bottle to see what's floating. But I think the buckyball structure itself is too large for miraculous pore dive expeditions.
#123
Posted 30 July 2013 - 08:08 PM
But I think the buckyball structure itself is too large for miraculous pore dive expeditions.
It's not really very big- only one nanometer in diameter, by itself. I'd be more concerned about the triglycerides that it's bound to. They increase size and MW considerably, but more importantly, the active species is almost certainly the fatty acid adduct rather than a triglyceride adduct, so the triglyceride needs to be digested (hydrolyzed) in order to form the active agent. That may or may not occur in skin, but is a normal part of our digestion of lipids.
#124
Posted 30 July 2013 - 09:40 PM
#125
Posted 31 July 2013 - 12:45 AM
My suggestion is obviously cryonics. If doctors today can't fix you and it puts your life in such shambles, live for tomorrow (though it may be fairly far away in terms of time). People who are well informed on cryonics feel that there is currently a 50-80% of being reanimated.... Neuro stasis/suspension starts at $10K plus transportation to Russia, the oldest Cryo company in the US charges $28-35K for domestic full body services depending on whether or not you pay ahead of time. Then there is always Alcor who's services last I checked run between $80K for neuro and $200K for whole body. Standby services run $88K through Suspended Animation IIRC. Rudi can give you all of the most up to date info.
Thanks, but that is really not an option. It is overkill to the nth degree to submit to cryogenic freezing with the hope that I may be revived, and if so, that there is will treatment and/or an understanding of this issue. And all of this for a skin issue and a life that I don't really care much for to begin with. It is like using a sledge-hammer for a thumb tack. I don't subscribe to the mostly erroneous notion of cultural/technological progress, anyways. I have no faith in the future whatsoever. I see it devolving in an increasingly dystopian fashion until our species finally eradicates itself, which won't be long...thankfully.
Often people who think so negatively as you seem to, don't understand the future or what we have at present. It would be a pitty to die early or to forgo a life that may someday prove you wrong. I'm not saying you get cryonics immediately, but that you've spent this life suffering from a disease you won't have in the next and that it'll change things for you. Probably for the better. If we indeed eradicate ourselves it will be through methods such as eugenics. You also don't know that you won't get thawed before the bomb drops (if that's what you expect) and have an opportunity to campaign against dropping it.
I had someone tell me once that they wouldn't want to live in the future and it was because he didn't think that a future who thawed cryonicists would be a successful or respectable one. He didn't think I was worth my existence either. He thought the same way you do. I wouldn't be surprised if you got that notion from someone who hated you.
Please do reconsider. Engineering can already rebuild us if given the time and massive sums of money required, now it's just a matter of ending aging. I'm working on methods of human molecular remanufacturing and I consider the solution to be in the box. For anyone who hasn't suffered a videogame style headshot with a shotgun, and who gets a quality preservation, the chances of being repaired are nearly 100% in favor of success. All the the tech needed to do what I'm talking about is published and it's just a matter of time until someone makes these techs commonplace and we're able to build and demonstrate the technology on the budget we have at that time.
Don't throw your life away!
#126
Posted 02 August 2013 - 10:52 PM
I used to have a lot of faith in nutrition, alternative/complimentary medicine...but I really do think that we are prisoners of genes, period. Nutrition likely does little to nothing to alter the course of one's life and nutritional supplements are quite possibly the biggest racket going. There may be a reason why nobody ever feels like supplements are actually doing anything. That's because they aren't. The nutritional supplement industry is largely a giant fucking scam. I am not much of a proponent for making anything in particular illegal, but I wouldn't mind one bit if the government or the WTA made supplements illegal, like the wild-eyed conspiracy theorists are always banging on about. It would save a lot of witless nitwits from wasting their money on fucking sugar pills. Why in the 21st century, we still tolerate the peddling snake oil to credulous morons is beyond me. One more testament to the inherently unscrupulous nature of the irrevocably fucked animal that is the human being.
Edited by Soma, 02 August 2013 - 11:13 PM.
#127
Posted 03 August 2013 - 02:54 PM
Edited by Ark, 03 August 2013 - 02:54 PM.
#128
Posted 04 August 2013 - 07:10 AM
I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me.
What skin condition do you have, if i may ask, that is worth considering suicide over?
#129
Posted 04 August 2013 - 01:34 PM
I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me.
What skin condition do you have, if i may ask, that is worth considering suicide over?
Something similar to, but not identical to ichthyosis, based on earlier discussions.
#130
Posted 04 August 2013 - 01:53 PM
I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me. I have come to see that persevering in the face of an insurmountable problem is really just another disease of the mind. We tend to praise people for this, as though it is valiant and heroic, but it is none of this...it is irrational, confused, and just torturously delays the inevitable. The hope that I would eventually find something to heal, reverse, or at least ameliorate this terrible problem has been the only thing, and I truly mean the only thing that has kept me going...but that hope is all but dead, hanging on by a cobweb. I am not afraid to die. Suffering is what I wish to avoid, not death.
Soma, you have a good reason to be depressed and angry. You have the psychological pain of thinking that you look like a monster, although I suspect that not everyone in your life is quite so put off by your appearance. You probably have physical pain associated with your condition. Modern medicine may not be able to cure you, but they are very good at dealing with physical pain. That part of your condition could be addressed medically, by a pain specialist if necessary. For the psychic pain, I'd take a look at cognitive behavioral therapy. CBT could train your mind to think differently about your situation, and in so doing, deal with much of the psychic pain. As far as having a reason to live, you're obviously intelligent and a good writer. Those skills could do good and could make you money.
I hope that you find a way out of your pain.
#131
Posted 04 August 2013 - 03:10 PM
As I have said before, I came to this site for its wealth of health information. Philosophically, I am distinct from most here. I am not a futurist, a trans-humanist, or proponent of an indefinite lifespan. I don't possess an unexamined, quasi-neurotic survival anxiety, which in my opinion, is quite obviously primary impetus of organization such as this, and implicitly in the near universal and insatiable human drives for money, power, status, and fame. I lack these drives. Even my basic animalistic survival instinct has been slowly but inexorably chipped away as well. In the end- like Ernest Becker- I am not a denier of death. I have transitioned from accepting it to welcoming it, as it may be the only way out of my pain.
#132
Posted 04 August 2013 - 03:32 PM
#133
Posted 05 August 2013 - 06:28 AM
If I didn't mention it before, the Society for Venturism raises money for those who can't afford cryonics. You should read about Aaron Winborn and Kim Suozzi. They are both brave souls who we'll see in the future. You really aren't alone and anything is possible.
#134
Posted 05 August 2013 - 06:45 AM
Edited by nowayout, 05 August 2013 - 06:46 AM.
#135
Posted 06 August 2013 - 05:43 AM
Sounds gross, but if you're brave and the case study follow data looks good...
You would probably be able to use your own blood cells and have the gene that causes it knocked out if they know which one it is.
Edited by cryonicsculture, 06 August 2013 - 05:45 AM.
#136
Posted 14 August 2013 - 03:36 PM
Te torment is too much to endure. Biological life is a horrible horrible accident. It would have been infinitely better had it never happened.
#137
Posted 24 August 2013 - 07:37 AM
I have never been a candidate for accutane as my skin is excessively dry to begin with.
Perhaps you are dismissing systemic retinoids too quickly?
Isotretinoin has apparently been used with success with people with ichthyyosis (as well as psoriasis, rosacea & acne).
If a dermatologist won't prescribe it, you could "self-prescribe" & purchase from an online pharmacy.
http://www.ncbi.nlm..../pubmed/7040514
J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):716-20.
Treatment of ichthyosis with isotretinoin.
Baden HP, Buxman MM, Weinstein GD, Yoder FW.
Abstract
A multicenter study of the effectiveness of 13-cis-retinoic acid (isotretinoin) in lamellar ichthyosis and epidermolytic hyperkeratosis has been conducted. A dose of the drug which produced maximum clearing with minimum side effects was chosen; this varied among different patients, the mean dose being about 2 mg/kg/day. Almost all of the patients in both groups were clearly improved, as evaluated both by the physicians and the patients. The degree of improvement seemed higher in the group of patients with lamellar ichthyosis.
PMID: 7040514 [PubMed - indexed for MEDLINE]
Tazarotene - used topically in gel form - seems to be useful in several kinds of ichthyosis:
http://www.ncbi.nlm....pubmed/12823301
Clin Exp Dermatol. 2003 Jul;28(4):391-3.
Type I lamellar ichthyosis improved by tazarotene 0.1% gel.
Abstract
The efficacy of tazarotene 0.1% gel in a 30-year-old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene-treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side-effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side-effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.
PMID: 12823301 [PubMed - indexed for MEDLINE]
Tazarotene gel can be ordered from alldaychemist for less than $10/ tube (if your dermatologist won't prescribe it).
Another systemic retinoid - Actitretin - appears to be a standard treatment for various types of ichthyosis. Did your dermatologist try it with you?
http://www.ncbi.nlm....pubmed/17263800
Br J Dermatol. 2007 May;156(5):965-73. Epub 2007 Jan 30.
Oral liarozole vs. acitretin in the treatment of ichthyosis: a phase II/III multicentre, double-blind, randomized, active-controlled study.
Abstract
BACKGROUND:
Liarozole, a retinoic acid metabolism blocking agent, has been granted orphan drug status for congenital ichthyosis by the European Commission and the U.S. Food and Drug Administration.
OBJECTIVES:
The purpose of this trial was to investigate the efficacy, tolerability and safety of oral liarozole vs. acitretin in patients with ichthyosis.
METHODS:
In this double-blind comparative trial of liarozole vs. acitretin, 32 patients with ichthyosis were randomized to be treated with either oral liarozole 75 mg in the morning and 75 mg in the evening or with acitretin 10 mg in the morning and 25 mg in the evening for 12 weeks. Clinical efficacy, tolerability and safety were monitored.
RESULTS:
Between-group comparisons for efficacy and tolerability revealed no statistically significant differences except for scaling on the trunk at baseline which was significantly worse in the liarozole group (P = 0.024) and showed a more pronounced improvement in this group than in the acitretin-treated patients (P = 0.047). Based on the overall evaluation of the response to treatment at endpoint, 10 of 15 patients in the liarozole group and 13 of 16 patients in the acitretin group were considered by the investigator to be at least markedly improved. The expected retinoic acid-related adverse events were mostly mild to moderate and tended to occur less frequently in the liarozole group. No serious adverse events related to the drugs occurred.
CONCLUSIONS:
The present study indicates that liarozole at a daily dose of 150 mg is equally effective as a treatment for ichthyosis as acitretin but shows a trend towards a more favourable tolerability profile. The results of this trial warrant further clinical trials to confirm efficacy and safety of liarozole as an orphan drug in ichthyosis.
Apologies if you have already explored some of these options.
#138
Posted 24 August 2013 - 08:38 AM
It sounds like teatment for depression should at this point be a priority. Please consider it.
Edited by nowayout, 24 August 2013 - 08:41 AM.
#139
Posted 09 September 2013 - 10:28 PM
Edited by mrd1, 09 September 2013 - 10:39 PM.
#140
Posted 11 September 2013 - 03:34 PM
Hmmm... I remember hearing about a case study where the patient's skin pretty much melted off as a reaction to a particular drug and they were able to regrow her skin from head to toe with stem cell infused sheets made from donor blood. I never was able to find the study, and it's probably been about 10 years since I initially heard about it. You might think about having some of your skin removed and regrown from your own modified cells in this way. If it works well (the case study chick had baby-like skin), you might think about regrowing your entire epidermis while in a drug induced coma.
Sounds gross, but if you're brave and the case study follow data looks good...
You would probably be able to use your own blood cells and have the gene that causes it knocked out if they know which one it is.
Soma, are you still here? I am afraid I do not have much to say but maybe you want to check this out. I remembered an anecdote from a person from very deep scars from acne. He had a very deep acid peel and regenarated his skin with the method described above. I am not sure about your financial situation but in any case have hope, this is something doable today. I am very sorry that people were not able to help you find a cure in your thread.
LLLT (low level laser therapi). I have build my own device using 650 laser diodes each providing 5 mW red laser light of 650 nm wavelenght. I build it to restore hair growth but it also have had a significant effect on my scalp skin. You can Either build one yourself (see www.overmachogrande.com for a DIY guide) or buy one via the same site. Sincerely hope this will help you
Hi HHM, could you describe this in more detail? What effects do you have from the laser on hair restoration and skin health?
#141
Posted 20 September 2013 - 11:21 AM
Soma, are you still here?
Soma's last post read to me like a suicide note.
#142
Posted 22 September 2013 - 12:05 AM
I just wanted to extend a sincere thank you everyone who tried to help me. I don't have anything left. I have no more will.
Te torment is too much to endure. Biological life is a horrible horrible accident. It would have been infinitely better had it never happened.
Soma I don't know if you will ever read this but I wanted to offer you a small thought all the same.
While nobody can fully appreciate what it is like to live with your condition there are people who make the choice to end their lives for far more trivial matters -- they think they are overweight, they perceive themselves as "failures" for any number of inane reasons, on and on. How many beautiful women go vomit after a meal because they think they are unattractive? You might dismiss them as not knowing what "true" suffering is like but outside of your physical discomfort your psychic pain is every bit as construed as theirs. And surely there are others in this world who would wish only to have your condition.
So much unhappiness and pain comes from the disconnect from what is with what we want or don't want. The more we resist and hinge out happiness on externalities the more we despair that we will never get "there." And even when we do manage to achieve this or that it is more often than not a temporary gratification.
Let go of it all -- the hopes of things changing, the idea of being cursed, the artifice of your self-opinion. Throw it all away! This isn't an attempt to push any religion on you but see if there is a mindfulness center near you. Learn to slowly find ways to shed this crushing mountain of self revulsion and psychic agony. It is possible. It is doable.
Though we will never meet I am one person who will hope that today is the day you begin to perceive and unlock all of the chains, traps, and other instruments you have been affixing to yourself.
Be well.
#143
Posted 22 September 2013 - 12:58 AM
I used a laser hair comb after I had a baby and my hair got very thin. My stylist (a guy) recommended it. It caused my hair to grow/thicken but I did not like it since the new hair came out coarse and wiry. I would recommend it to men who keep their hair short, however. My hair grew in much thicker after I started taking B vitamins; Biosil helps, too. I didn't notice any skin changes from using the laser comb.
I still have the comb around here somewhere...
#144
Posted 03 April 2014 - 09:58 PM
Soma's last post read to me like a suicide note.
No, I'm still here. I took a long break from everything. I am still struggling immensely...but thank you for caring. I'm strongly considering C60oo, but I certainly don't expect much. If it can help at all, I would be appreciative.
#145
Posted 04 April 2014 - 12:44 AM
#146
Posted 04 April 2014 - 05:01 PM
I suppose a three month course would be long enough to fairly judge the potential of this substance vis-à-vis my particular condition and any improvements I may receive. Does this seem like a fair trial period?
#147
Posted 25 April 2014 - 11:19 PM
Have you ever tried immunomodulators, like elidel (aka pimecrolimus) and protopic (aka tacrolimus)? Maybe even a low-dose systemic immunomodulator - under supervision obviously - to see how your skin reacts?
https://en.wikipedia...ki/Pimecrolimus
https://en.wikipedia...wiki/Tacrolimus
What about light therapy? Or alternatively a good dose of natural sunlight daily?
https://en.wikipedia...i/Light_therapy
Do you know if you have an allergy? Have you ever had a thorough skin allergy test?
https://en.wikipedia...in_allergy_test
Have you ever been tested for (late-onset) biotinidase deficiency?
https://en.wikipedia...dase_deficiency
Like suggested earlier, I would also consider isotretinoin or even topical tretinoin. Dryness could be alleviated with a good moisturizer.
https://en.wikipedia...ki/Isotretinoin
https://en.wikipedia.../wiki/Tretinoin
Things like calcipotriol, lithium gluconate, zinc PCA, azelaic acid, benzoic acid, salicylic acid, resorcinol, urea, epsom salt, oregano oil, ciclopirox and metronidazole, might be worth a try as well.
https://en.wikipedia...ki/Calcipotriol
https://en.wikipedia...ki/Azelaic_acid
https://en.wikipedia...ki/Benzoic_acid
https://en.wikipedia.../Salicylic_acid
https://en.wikipedia...wiki/Resorcinol
https://en.wikipedia.org/wiki/Urea
https://en.wikipedia...gnesium_sulfate
https://en.wikipedia...wiki/Ciclopirox
https://en.wikipedia...i/Metronidazole
As for the scars, there are many options to tackle those. With dermabrasion, CO2 laser resurfacing, chemical peels, collagen injections, silicone gel/sheets, small skin grafts and cosmetic camouflage, tremendous improvement is possible.
https://en.wikipedia...ki/Dermabrasion
https://en.wikipedia...n_dioxide_laser
https://en.wikipedia...i/Chemical_peel
https://en.wikipedia...en#Medical_uses
https://en.wikipedia...cone_scar_sheet
https://en.wikipedia...i/Skin_grafting
https://en.wikipedia...etic_camouflage
I would also seriously seek treatment for your depression. Not only will you feel better, it could help your skin too. Psychological distress is a known eczema trigger.
#148
Posted 27 April 2014 - 12:43 PM
How about looking at digestive issues? I've noticed that addressing SIBO & Candida helped my skin.
Here-s an example - after ingesting a lot of coconut oil every day (was taking 4-5tbsp per day and now just 1-2 in my morning coffee) I had the bags and darkness under my eyes improve.
Taking collagen has given my face somewhat of a 'glow'.
But none of this is miraculous. I have very dry/scaly skin on my legs and my feet are dried and heels are very rough - in spite of my skin being less dry overall and my face improving my legs/feet are pretty much the same.
Even applying coconut oil topically daily doesn't fix it.
#149
Posted 27 April 2014 - 02:11 PM
How about looking at digestive issues? I've noticed that addressing SIBO & Candida helped my skin.
Good point. I realize that Soma doesn't have rosacea, but the following report does show that intestinal issues could be detrimental to our skin:
http://www.ncbi.nlm....pubmed/18456568
Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication.
Abstract
BACKGROUND & AIMS:To better understand the role of small intestinal bacterial overgrowth (SIBO) in rosacea, we aimed to assess the presence of SIBO in patients with rosacea and the clinical effectiveness of its eradication.
METHODS:We enrolled 113 consecutive rosacea ambulatory patients (31 M/82 F; mean age, 52 +/- 15 years) and 60 healthy controls who were sex- and age-matched. Patients and controls underwent lactulose and glucose breath tests (BTs) to assess the presence of SIBO. Patients positive for SIBO were randomized to receive rifaximin therapy (1200 mg/day for 10 days) or placebo. A group of patients with negative BTs were also treated with rifaximin. Eradication was assessed 1 month after the end of therapy. Two dermatologists, unblinded on therapy, evaluated rosacea patients before and after treatment on the basis of an objective scale.
RESULTS:The prevalence of SIBO was higher in patients than controls (52/113 vs 3/60, P < .001). After eradication, cutaneous lesions cleared in 20 of 28 and greatly improved in 6 of 28 patients, whereas patients treated with placebo remained unchanged (18/20) or worsened (2/20) (P < .001). Placebo patients were subsequently switched to rifaximin therapy, and SIBO was eradicated in 17 of 20 cases. Fifteen had a complete resolution of rosacea. After antibiotic therapy, 13 of 16 patients with negative BTs for SIBO remained unchanged, and this result differed from SIBO-positive cases (P < .001).
CONCLUSIONS:This study demonstrated that rosacea patients have a significantly higher SIBO prevalence than controls. Moreover, eradication of SIBO induced an almost complete regression of their cutaneous lesions and maintained this excellent result for at least 9 months.
Colloidal oatmeal baths could be helpful, too. It's very easy to make and relatively cheap. Buy some oats, grind them to a fine powder and pour a couple cups in a bath:
A vastly diluted bleach bath is also helpful for some people with eczema:
http://www.newscient...ct-on-skin.html
http://www.aaaai.org...conditions.aspx
Topical vitamin B12 is worth exploring as well:
http://www.ncbi.nlm....pubmed/15149512
And applying cream and then covering the area in cellophane foil greatly helped this ichthyosis patient:
#150
Posted 29 April 2014 - 01:14 AM
My general rule of thumb is the majority of problems you're facing will be MUCH better once you focus on healing the gut - Candida, SIBO, H. Pylori over growth etc..
Simply eliminating foods we have sensitivities too - gluten, dairy, eggs, soy, corn (it depends on YOU but for most of us traditional dairy and gluten are a problem) is another amazing "biohack".
Fixing these underlying problems has REALLY improved the quality of my life in just about every aspect - weight, mental health, focus, levelness of mood etc..
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